DegronMD - P18583(SON)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L673M	TCGA-05-4396	LUAD	TCGA	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.2778
p.L673M	DO23838	LUAD	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.2778
p.E1656K	TCGA-77-A5GB	LUSC	TCGA	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.E1656K	DO45439	LUSC	ICGC	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.0556
p.P423S	TCGA-78-7149	LUAD	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.6752
p.P423S	DO23790	LUAD	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.6752
p.P423S	DO220851	MELA	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.6752
p.E315K	TCGA-78-7539	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.E315K	DO26210	LUAD	ICGC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1944
p.E505K	TCGA-A5-A0G1	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.E505K	TCGA-HU-A4GX	STAD	TCGA	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.E505K	DO47757	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.E505K	DO42472	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.T325A	TCGA-A5-A0G2	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.T325A	DO41235	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.S1387L	TCGA-A5-A2K5	UCEC	TCGA	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7667
p.S1387L	TCGA-DR-A0ZM	CESC	TCGA	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7667
p.S1387L	DO217865	BRCA	ICGC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7667
p.S1387L	DO6254	CESC	ICGC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7667
p.S1387L	DO41379	UCEC	ICGC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7667
p.A1515S	TCGA-A6-3809	COAD	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.A1515S	DO8722	COAD	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.P676S	TCGA-AA-3672	COAD	TCGA	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.5641
p.P676S	DO9010	COAD	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.5641
p.S670L	TCGA-AP-A0LM	UCEC	TCGA	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.S670L	DO43306	UCEC	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.S670L	SIDM00958	Chronic Myelogenous Leukemia	GDSC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.S670L	ACH-000920	Leukemia	CCLE	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.F2153L	TCGA-B5-A1MR	UCEC	TCGA	PTPPKS	DEG_SCF_FBW7_1	2162:2167	Mutation rewiring degron network	0.0833
p.F2153L	DO41758	UCEC	ICGC	PTPPKS	DEG_SCF_FBW7_1	2162:2167	Mutation rewiring degron network	0.0833
p.A1515D	TCGA-B5-A1MX	UCEC	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.A1515D	DO41999	UCEC	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.E2134K	TCGA-BA-5152	HNSC	TCGA	PPFY	ITCH	2136:2139	Mutation rewiring degron network	0.2778
p.E2134K	DO14393	HNSC	ICGC	PPFY	ITCH	2136:2139	Mutation rewiring degron network	0.2778
p.P320R	TCGA-BA-6873	HNSC	TCGA	PSTST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7512
p.P320R	DO14242	HNSC	ICGC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7512
p.S1379L	TCGA-BG-A0VZ	UCEC	TCGA	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1667
p.S1379L	TCGA-D1-A15X	UCEC	TCGA	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1667
p.S1379L	TCGA-HU-A4G9	STAD	TCGA	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1667
p.S1379L	DO47789	STAD	ICGC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1667
p.S1379L	DO42368	UCEC	ICGC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1667
p.S1379L	DO43274	UCEC	ICGC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1667
p.S283T	TCGA-BR-8680	STAD	TCGA	VESTS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7116
p.S283T	DO47769	STAD	ICGC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.7116
p.S390C	TCGA-C8-A26Y	BRCA	TCGA	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.1389
p.S390C	DO1273	BRCA	ICGC	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.1389
p.S2129L	TCGA-CG-4460	STAD	TCGA	PPFY	ITCH	2136:2139	Mutation blocking phosphorylation signal	0.5833
p.S2129L	DO38427	STAD	ICGC	PPFY	ITCH	2136:2139	Mutation blocking phosphorylation signal	0.5833
p.G2358V	TCGA-D3-A3C6	SKCM	TCGA	DRKGLVAVG	DEG_APCC_DBOX_1	2342:2350	Mutation rewiring degron network	0.1111
p.K2149T	TCGA-DK-A6AW	BLCA	TCGA	PPFY	ITCH	2136:2139	Mutation substituting flanking lysine	0.1667
p.K2149T	DO48566	BLCA	ICGC	PPFY	ITCH	2136:2139	Mutation substituting flanking lysine	0.1667
p.S331L	TCGA-DK-A6B6	BLCA	TCGA	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.S331L	DO48576	BLCA	ICGC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.1389
p.S390F	TCGA-EE-A29D	SKCM	TCGA	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.1389
p.S390F	DO38123	SKCM	ICGC	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.1389
p.L420F	TCGA-EE-A3AE	SKCM	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.587
p.L420F	DO37802	SKCM	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.587
p.K2149Q	TCGA-EJ-7793	PRAD	TCGA	PPFY	ITCH	2136:2139	Mutation substituting flanking lysine	0.1667
p.K2149Q	DO36323	PRAD	ICGC	PPFY	ITCH	2136:2139	Mutation substituting flanking lysine	0.1667
p.T411S	TCGA-EK-A2R7	CESC	TCGA	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation altering degron motif	0.7116
p.T411S	DO49943	CESC	ICGC	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation altering degron motif	0.7116
p.H1508Y	TCGA-G4-6586	COAD	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.3056
p.H1508Y	DO9698	COAD	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.3056
p.A1515V	TCGA-GN-A26C	SKCM	TCGA	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.A1515V	DO37782	SKCM	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.P430L	TCGA-HR-A5NC	SKCM	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation rewiring degron network	0.2222
p.P430L	DO51265	SKCM	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation rewiring degron network	0.2222
p.S677L	TCGA-HT-8564	LGG	TCGA	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.7667
p.S677L	DO44623	LGG	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.7667
p.E426Q	TCGA-XF-A9T2	BLCA	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.6744
p.E426Q	DO51921	BLCA	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.6744
p.E293K	TCGA-YC-A89H	BLCA	TCGA	VESTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.E293K	DO51948	BLCA	ICGC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.0556
p.P1249A	DO233958	BPLL	ICGC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation rewiring degron network	0.0556
p.S409C	DO1129	BRCA	ICGC	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation altering degron motif	0.643
p.D423G	DO4080	BRCA	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.7198
p.E417D	DO8264	COAD	ICGC	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation rewiring degron network	0.2778
p.E417D	DO8264	COAD	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation rewiring degron network	0.2778
p.M1502I	DO229010	COCA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation altering degron motif	0.6507
p.M1502I	DO229013	COCA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation altering degron motif	0.6507
p.M1502I	DO229003	COCA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation altering degron motif	0.6507
p.M1502I	DO229505	LAML	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation altering degron motif	0.6507
p.M1502I	DO230527	LUSC	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation altering degron motif	0.6507
p.P507R	DO50339	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.7512
p.I1487V	DO233073	GACA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.0833
p.N1495S	DO233203	GACA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.3056
p.H1273R	DO233195	GACA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation rewiring degron network	0.1389
p.N685S	DO233734	GACA	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1667
p.Q1503L	DO233854	GACA	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation altering degron motif	0.6654
p.S665A	DO49533	LAML	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0556
p.S665A	DO231260	LAML	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0556
p.L1261F	DO228835	LICA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation altering degron motif	0.587
p.V1276F	DO228976	LICA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation rewiring degron network	0.0556
p.V1276F	DO228976	LICA	ICGC	VSETPAMS	DEG_SCF_FBW7_1	1285:1292	Mutation rewiring degron network	0.0833
p.M405I	DO228976	LICA	ICGC	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.3056
p.M405I	DO228976	LICA	ICGC	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation rewiring degron network	0.25
p.M519I	DO229015	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1111
p.Q671H	DO229029	LICA	ICGC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.2222
p.L503F	DO229034	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2222
p.W320L	DO229036	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation altering degron motif	0.7015
p.A319S	DO229006	LICA	ICGC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.3056
p.D1493V	DO231658	LINC	ICGC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.25
p.S1378F	DO34640	PACA	ICGC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1389
p.P1263H	DO35442	PACA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation altering degron motif	0.7694
p.E285D	DO232761	PBCA	ICGC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.2778
p.P416H	DO47619	SKCM	ICGC	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation rewiring degron network	0.3056
p.P416H	DO47619	SKCM	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation rewiring degron network	0.25
p.T678M	SIDM00611	Kidney Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.7423
p.T678M	ACH-000684	Kidney Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.7423
p.T678M	KMRC-1	kidney	COSMIC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.7423
p.P417S	SIDM00845	Burkitt's Lymphoma	GDSC	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation rewiring degron network	0.2778
p.P417S	SIDM00845	Burkitt's Lymphoma	GDSC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation rewiring degron network	0.2778
p.L513F	SIDM00845	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.L513F	SIDM00035	Thyroid Gland Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.L513F	SIDM00461	Acute Myeloid Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.L513F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.L513F	SIDM01519	Head and Neck Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.L513F	ACH-000786	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.L513F	Daudi	haematopoietic and lymphoid tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.2778
p.G518A	SIDM00845	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.G518A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.G518A	SIDM00461	Acute Myeloid Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.G518A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.G518A	SIDM01519	Head and Neck Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.G518A	ACH-000786	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.G518A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation rewiring degron network	0.1389
p.N1488S	SIDM00969	Ovarian Carcinoma	GDSC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.N1488S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LAPEIGMQEIAL	DEG_ODPH_VHL_1	1496:1507	Mutation rewiring degron network	0.1111
p.V675A	SIDM01248	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.5825
p.V675A	SIDM01167	Thyroid Gland Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.5825
p.V675A	ACH-000163	Thyroid Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.5825
p.V675A	ACH-001023	Thyroid Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.5825
p.V675A	CGTH-W-1	thyroid	COSMIC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.5825
p.T510S	SIDM00652	Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.6005
p.T510S	ACH-000780	Lung Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	507:511	Mutation altering degron motif	0.6005
p.S281N	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.818
p.S281N	ACH-002256	Leukemia	CCLE	VESTS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.818
p.S281N	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation altering degron motif	0.818
p.T1637I	SIDM00555	Glioblastoma	GDSC	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1944
p.T1637I	ACH-000631	Brain Cancer	CCLE	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1944
p.T1637I	KS-1	central nervous system	COSMIC	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.1944
p.M667I	SIDM00188	Kidney Carcinoma	GDSC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1111
p.M667I	ACH-002139	Kidney Cancer	CCLE	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1111
p.M667I	HA7-RCC	kidney	COSMIC	VPSTT	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1111
p.K288N	SIDM00267	Biliary Tract Carcinoma	GDSC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation blocking ubiquitination signal	0.6389
p.K288N	ACH-002312	Gallbladder Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	279:283	Mutation blocking ubiquitination signal	0.6389
p.K288N	TGBC24TKB	biliary tract	COSMIC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation blocking ubiquitination signal	0.6389
p.L276M	SIDM01218	Other Solid Cancers	GDSC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.25
p.L276M	ACH-001530	Endometrial/Uterine Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.25
p.L276M	JEG-3	placenta	COSMIC	VESTS	DEG_SPOP_SBC_1	279:283	Mutation rewiring degron network	0.25
p.L394F	SIDM00578	Neuroblastoma	GDSC	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.25
p.L394F	ACH-000804	Neuroblastoma	CCLE	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.25
p.L394F	NB1	autonomic ganglia	COSMIC	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.25
p.M326I	SIDM01118	Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.M326I	SIDM00710	Small Cell Lung Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.M326I	SIDM01759	Hodgkin's Lymphoma	GDSC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2778
p.V424L	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.5654
p.V424L	ACH-000826	Lung Cancer	CCLE	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.5654
p.V424L	CAL-12T	lung	COSMIC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.5654
p.G1650A	SIDM01190	Bladder Carcinoma	GDSC	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.2222
p.G1650A	ACH-000720	Bladder Cancer	CCLE	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.2222
p.G1650A	TCCSUP	urinary tract	COSMIC	VISTS	DEG_SPOP_SBC_1	1642:1646	Mutation rewiring degron network	0.2222
p.P1392L	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7582
p.P1392L	ACH-000596	Lung Cancer	CCLE	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7582
p.P1392L	LCLC-97TM1	lung	COSMIC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation altering degron motif	0.7582
p.A1270V	SIDM00220	Ovarian Carcinoma	GDSC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation rewiring degron network	0.2222
p.A1290T	SIDM01608	Endometrial Carcinoma	GDSC	VSETPAMS	DEG_SCF_FBW7_1	1285:1292	Mutation altering degron motif	0.6028
p.A1290T	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSETPAMS	DEG_SCF_FBW7_1	1285:1292	Mutation altering degron motif	0.6028
p.E1256G	SIDM01749	Osteosarcoma	GDSC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation rewiring degron network	0.25
p.E1256G	SIDM01752	Pancreatic Carcinoma	GDSC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation rewiring degron network	0.25
p.P426H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation altering degron motif	0.7694
p.G316D	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2222
p.G316D	HCT-15	large intestine	COSMIC	PSTST	DEG_SPOP_SBC_1	320:324	Mutation rewiring degron network	0.2222
p.P397S	ACH-002161	Gastric Cancer	CCLE	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation altering degron motif	0.6752
p.P397S	MKN28	stomach	COSMIC	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation altering degron motif	0.6752
p.S1378P	ARH-77	haematopoietic and lymphoid tissue	COSMIC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1389
p.S1378P	D-245MG	central nervous system	COSMIC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1389
p.S1378P	LB647-SCLC	lung	COSMIC	EPSVVTVPEP	DEG_COP1_1	1385:1394	Mutation rewiring degron network	0.1389
p.P416S	ST486	haematopoietic and lymphoid tissue	COSMIC	PSATPVPE	DEG_SCF_FBW7_2	408:415	Mutation rewiring degron network	0.3056
p.P416S	ST486	haematopoietic and lymphoid tissue	COSMIC	PLSTPVPE	DEG_SCF_FBW7_2	419:426	Mutation rewiring degron network	0.25
p.P1249S	NCI-H524	lung	COSMIC	ITLTPVES	DEG_SCF_FBW7_1	1259:1266	Mutation rewiring degron network	0.0556
p.P1295Q	ML-2	haematopoietic and lymphoid tissue	COSMIC	VSETPAMS	DEG_SCF_FBW7_1	1285:1292	Mutation rewiring degron network	0.25
p.M392R	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	PPVTPVLE	DEG_SCF_FBW7_2	397:404	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SON

UniProt ID: P18583

Entrez ID: 6651

Protein name: Protein SON (Bax antagonist selected in saccharomyces 1) (BASS1) (Negative regulatory element-binding protein) (NRE-binding protein) (Protein DBP-5) (SON3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SON in