DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_COP1_1

Location: 1385:1394

E3 ligase: COP1

DEGRON score: 0.9542

ASA_SCORE: 100.72

COIL: 0.9493

CONS_SCORE: 0.7726

DSS_SCORE: 0.27

HELIX: 0.0084

FCONS_SCORE: 1.002

RIG_SCORE: 0.7924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1387L	TCGA-A5-A2K5	UCEC	TCGA	EPSVVTVPEP	DEG_COP1_1	0.7667
p.S1387L	TCGA-DR-A0ZM	CESC	TCGA	EPSVVTVPEP	DEG_COP1_1	0.7667
p.S1387L	DO217865	BRCA	ICGC	EPSVVTVPEP	DEG_COP1_1	0.7667
p.S1387L	DO6254	CESC	ICGC	EPSVVTVPEP	DEG_COP1_1	0.7667
p.S1387L	DO41379	UCEC	ICGC	EPSVVTVPEP	DEG_COP1_1	0.7667
p.S1379L	TCGA-BG-A0VZ	UCEC	TCGA	EPSVVTVPEP	DEG_COP1_1	0.1667
p.S1379L	TCGA-D1-A15X	UCEC	TCGA	EPSVVTVPEP	DEG_COP1_1	0.1667
p.S1379L	TCGA-HU-A4G9	STAD	TCGA	EPSVVTVPEP	DEG_COP1_1	0.1667
p.S1379L	DO47789	STAD	ICGC	EPSVVTVPEP	DEG_COP1_1	0.1667
p.S1379L	DO42368	UCEC	ICGC	EPSVVTVPEP	DEG_COP1_1	0.1667
p.S1379L	DO43274	UCEC	ICGC	EPSVVTVPEP	DEG_COP1_1	0.1667
p.S1378F	DO34640	PACA	ICGC	EPSVVTVPEP	DEG_COP1_1	0.1389
p.P1392L	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	EPSVVTVPEP	DEG_COP1_1	0.7582
p.P1392L	ACH-000596	Lung Cancer	CCLE	EPSVVTVPEP	DEG_COP1_1	0.7582
p.P1392L	LCLC-97TM1	lung	COSMIC	EPSVVTVPEP	DEG_COP1_1	0.7582
p.S1378P	ARH-77	haematopoietic_and_lymphoid_tissue	COSMIC	EPSVVTVPEP	DEG_COP1_1	0.1389
p.S1378P	D-245MG	central_nervous_system	COSMIC	EPSVVTVPEP	DEG_COP1_1	0.1389
p.S1378P	LB647-SCLC	lung	COSMIC	EPSVVTVPEP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18583	Protein SON	DEG_COP1_1	1385:1394	EPSVVTVPEP	COP1	0.9542	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons