DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SCF_FBW7_1

Location: 1259:1266

E3 ligase: FBXW7

DEGRON score: 0.8871

ASA_SCORE: 96.625

COIL: 0.9124

CONS_SCORE: 0.804

DSS_SCORE: 0.5835

HELIX: 0.0191

FCONS_SCORE: 1.0237

RIG_SCORE: 0.7278

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1249A	DO233958	BPLL	ICGC	ITLTPVES	DEG_SCF_FBW7_1	0.0556
p.H1273R	DO233195	GACA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	0.1389
p.L1261F	DO228835	LICA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	0.587
p.V1276F	DO228976	LICA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	0.0556
p.P1263H	DO35442	PACA	ICGC	ITLTPVES	DEG_SCF_FBW7_1	0.7694
p.A1270V	SIDM00220	Ovarian Carcinoma	GDSC	ITLTPVES	DEG_SCF_FBW7_1	0.2222
p.E1256G	SIDM01749	Osteosarcoma	GDSC	ITLTPVES	DEG_SCF_FBW7_1	0.25
p.E1256G	SIDM01752	Pancreatic Carcinoma	GDSC	ITLTPVES	DEG_SCF_FBW7_1	0.25
p.P1249S	NCI-H524	lung	COSMIC	ITLTPVES	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18583	Protein SON	DEG_SCF_FBW7_1	1259:1266	ITLTPVES	FBXW7	0.8871	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons