DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SCF_FBW7_2

Location: 419:426

E3 ligase: FBXW7

DEGRON score: 0.8157

ASA_SCORE: 98.95

COIL: 0.9535

CONS_SCORE: 0.7739

DSS_SCORE: 0.6584

HELIX: 0.0124

FCONS_SCORE: 1.012

RIG_SCORE: 0.6006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P423S	TCGA-78-7149	LUAD	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	0.6752
p.P423S	DO23790	LUAD	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.6752
p.P423S	DO220851	MELA	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.6752
p.L420F	TCGA-EE-A3AE	SKCM	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	0.587
p.L420F	DO37802	SKCM	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.587
p.P430L	TCGA-HR-A5NC	SKCM	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	0.2222
p.P430L	DO51265	SKCM	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.2222
p.E426Q	TCGA-XF-A9T2	BLCA	TCGA	PLSTPVPE	DEG_SCF_FBW7_2	0.6744
p.E426Q	DO51921	BLCA	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.6744
p.D423G	DO4080	BRCA	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.7198
p.E417D	DO8264	COAD	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.2778
p.P416H	DO47619	SKCM	ICGC	PLSTPVPE	DEG_SCF_FBW7_2	0.25
p.P417S	SIDM00845	Burkitt's Lymphoma	GDSC	PLSTPVPE	DEG_SCF_FBW7_2	0.2778
p.V424L	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PLSTPVPE	DEG_SCF_FBW7_2	0.5654
p.V424L	ACH-000826	Lung Cancer	CCLE	PLSTPVPE	DEG_SCF_FBW7_2	0.5654
p.V424L	CAL-12T	lung	COSMIC	PLSTPVPE	DEG_SCF_FBW7_2	0.5654
p.P426H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PLSTPVPE	DEG_SCF_FBW7_2	0.7694
p.P416S	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTPVPE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18583	Protein SON	DEG_SCF_FBW7_2	419:426	PLSTPVPE	FBXW7	0.8157	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons