DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SCF_FBW7_1

Location: 1285:1292

E3 ligase: FBXW7

DEGRON score: 0.8877

ASA_SCORE: 100.8125

COIL: 0.9466

CONS_SCORE: 0.771

DSS_SCORE: 0.5131

HELIX: 0.023

FCONS_SCORE: 0.9889

RIG_SCORE: 0.7208

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1276F	DO228976	LICA	ICGC	VSETPAMS	DEG_SCF_FBW7_1	0.0833
p.A1290T	SIDM01608	Endometrial Carcinoma	GDSC	VSETPAMS	DEG_SCF_FBW7_1	0.6028
p.A1290T	ACH-000990	Endometrial/Uterine Cancer	CCLE	VSETPAMS	DEG_SCF_FBW7_1	0.6028
p.P1295Q	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	VSETPAMS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18583	Protein SON	DEG_SCF_FBW7_1	1285:1292	VSETPAMS	FBXW7	0.8877	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons