DegronMD

Uniprot ID: P18583

Source protein: Protein SON

Source gene: SON

Class: DEG_SPOP_SBC_1

Location: 507:511

E3 ligase: SPOP

DEGRON score: 0.6512

ASA_SCORE: 89.1

COIL: 0.8718

CONS_SCORE: 0.7831

DSS_SCORE: 0.5871

HELIX: 0.0206

FCONS_SCORE: 1.0098

RIG_SCORE: 0.7709

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E505K	TCGA-A5-A0G1	UCEC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.2778
p.E505K	TCGA-HU-A4GX	STAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.2778
p.E505K	DO47757	STAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.E505K	DO42472	UCEC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.P507R	DO50339	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7512
p.M519I	DO229015	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.L503F	DO229034	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.2222
p.L513F	SIDM00845	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.L513F	SIDM00035	Thyroid Gland Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.L513F	SIDM00461	Acute Myeloid Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.L513F	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.L513F	SIDM01519	Head and Neck Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.L513F	ACH-000786	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	0.2778
p.L513F	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.2778
p.G518A	SIDM00845	Burkitt's Lymphoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.G518A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.G518A	SIDM00461	Acute Myeloid Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.G518A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.G518A	SIDM01519	Head and Neck Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.G518A	ACH-000786	Lymphoma	CCLE	PVTTT	DEG_SPOP_SBC_1	0.1389
p.G518A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.T510S	SIDM00652	Small Cell Lung Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.6005
p.T510S	ACH-000780	Lung Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons