DegronMD

Uniprot ID: Q96D42

Source protein: Hepatitis A virus cellular receptor 1

Source gene: HAVCR1

Class: DEG_SPOP_SBC_1

Location: 203:207

E3 ligase: SPOP

DEGRON score: 0.9927

ASA_SCORE: 81.56

COIL: 0.7844

CONS_SCORE: 0.3508

DSS_SCORE: 0.4801

HELIX: 0.0262

FCONS_SCORE: 1.1106

RIG_SCORE: 0.782

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T206K	TCGA-13-1481	OV	TCGA	PVTTT	DEG_SPOP_SBC_1	0.7306
p.T206K	DO31789	OV	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7306
p.V204L	TCGA-D6-A4ZB	HNSC	TCGA	PVTTT	DEG_SPOP_SBC_1	0.5654
p.V204L	DO44446	HNSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.5654
p.V208I	TCGA-EB-A431	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.3056
p.V208I	DO37671	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.3056
p.P203S	TCGA-EJ-5527	PRAD	TCGA	PVTTT	DEG_SPOP_SBC_1	0.6752
p.P203S	TCGA-YG-AA3N	SKCM	TCGA	PVTTT	DEG_SPOP_SBC_1	0.6752
p.P203S	DO36322	PRAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.6752
p.P203S	DO51298	SKCM	ICGC	PVTTT	DEG_SPOP_SBC_1	0.6752
p.T207A	DO229010	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T207A	DO229005	COCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T207A	DO234285	ESAD	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T207A	DO230934	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T207A	DO231196	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.T207A	DO231201	LUSC	ICGC	PVTTT	DEG_SPOP_SBC_1	0.7139
p.S195R	DO223007	ESCA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.P214T	DO220902	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1389
p.M215L	DO222710	MELA	ICGC	PVTTT	DEG_SPOP_SBC_1	0.1111
p.T210A	SIDM00120	Prostate Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.25
p.T210A	ACH-000979	Prostate Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	0.25
p.T210A	DU-145	prostate	COSMIC	PVTTT	DEG_SPOP_SBC_1	0.25
p.P213S	SIDM00630	Breast Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NKB5	Pecanex-like protein 2	DEG_SPOP_SBC_1	2000:2004	PVTTT	SPOP	0.9571	More...
O43283	Mitogen-activated protein kinase kinase kinase 13	DEG_SPOP_SBC_1	63:67	PVTTT	SPOP	0.9958	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2870:2874	PVTTT	SPOP	0.5381	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2876:2880	PVTTT	SPOP	0.9639	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2882:2886	PVTTT	SPOP	0.8697	More...
P12111	Collagen alpha-3	DEG_SPOP_SBC_1	2889:2893	PVTTT	SPOP	0.991	More...
P18583	Protein SON	DEG_SPOP_SBC_1	507:511	PVTTT	SPOP	0.6512	More...
P27540	Aryl hydrocarbon receptor nuclear translocator	DEG_SPOP_SBC_1	530:534	PVTTT	SPOP	0.9876	More...
P36956	Sterol regulatory element-binding protein 1	DEG_SPOP_SBC_1	224:228	PVTTT	SPOP	0.9066	More...
P49848	Transcription initiation factor TFIID subunit 6	DEG_SPOP_SBC_1	570:574	PVTTT	SPOP	0.5016	More...
P98088	Mucin-5AC	DEG_SPOP_SBC_1	3488:3492	PVTTT	SPOP	0.525	More...
Q14896	Myosin-binding protein C, cardiac-type	DEG_SPOP_SBC_1	955:959	PVTTT	SPOP	0.8503	More...
Q8WZ42	Titin	DEG_SPOP_SBC_1	33135:33139	PVTTT	SPOP	0.9908	More...
Q96D42	Hepatitis A virus cellular receptor 1	DEG_SPOP_SBC_1	203:207	PVTTT	SPOP	0.9927	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	665:669	PVTTT	SPOP	0.9936	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	616:620	PVTTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons