DegronMD - Q7Z2K8(GPRIN1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1005T	TCGA-05-4384	LUAD	TCGA	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation rewiring degron network	0.0556
p.P1005T	DO23618	LUAD	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation rewiring degron network	0.0556
p.P586S	TCGA-17-Z058	LUAD	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2222
p.P586S	TCGA-AP-A1DV	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2222
p.P586S	DO43186	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2222
p.Q49E	TCGA-21-1077	LUSC	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation rewiring degron network	0.1111
p.Q49E	DO26725	LUSC	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation rewiring degron network	0.1111
p.G614W	TCGA-23-2641	OV	TCGA	PVTTT	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2778
p.G614W	DO31574	OV	ICGC	PVTTT	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.2778
p.S714R	TCGA-2G-AAGO	TGCT	TCGA	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation blocking phosphorylation signal	0.6111
p.Q49K	TCGA-44-6145	LUAD	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation rewiring degron network	0.1111
p.Q49K	DO25123	LUAD	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation rewiring degron network	0.1111
p.R729C	TCGA-50-5930	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1944
p.R729C	DO25189	LUAD	ICGC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1944
p.P61H	TCGA-73-4666	LUAD	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation altering degron motif	0.7694
p.P61H	DO26230	LUAD	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation altering degron motif	0.7694
p.G114E	TCGA-97-A4M3	LUAD	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.25
p.G114E	DO218937	LUAD	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.25
p.S587L	TCGA-AA-3845	COAD	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.1944
p.S587L	TCGA-AX-A2HC	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.1944
p.S587L	DO10020	COAD	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.1944
p.S587L	DO41572	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.1944
p.D591Y	TCGA-AA-A010	COAD	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.0833
p.E753D	TCGA-AP-A0LM	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.3056
p.E753D	DO43306	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.3056
p.A989V	TCGA-AP-A1DK	UCEC	TCGA	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation altering degron motif	0.5825
p.A989V	DO42033	UCEC	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation altering degron motif	0.5825
p.E130D	TCGA-AX-A2HC	UCEC	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1667
p.E130D	DO41572	UCEC	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1667
p.D767Y	TCGA-AX-A2HD	UCEC	TCGA	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0833
p.D767Y	DO42608	UCEC	ICGC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.0833
p.L110F	TCGA-B5-A3FA	UCEC	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1389
p.L110F	DO52402	UCEC	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1389
p.S134F	TCGA-BF-AAP2	SKCM	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0556
p.S134F	DO219466	SKCM	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.0556
p.R998L	TCGA-BR-A4QL	STAD	TCGA	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation rewiring degron network	0.25
p.R998L	DO38723	STAD	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation rewiring degron network	0.25
p.P584S	TCGA-BS-A0UV	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2778
p.P584S	DO42793	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2778
p.V748M	TCGA-CV-5443	HNSC	TCGA	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1667
p.V748M	DO15911	HNSC	ICGC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1667
p.P584Q	TCGA-DI-A1BU	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2778
p.P584Q	DO42023	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2778
p.G567V	TCGA-EE-A2GT	SKCM	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.1111
p.G567V	DO37946	SKCM	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.1111
p.P147S	TCGA-ER-A19K	SKCM	TCGA	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation altering degron motif	0.5641
p.P147S	DO47672	SKCM	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation altering degron motif	0.5641
p.P61L	TCGA-FS-A1Z0	SKCM	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation altering degron motif	0.7582
p.P61L	DO37431	SKCM	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation altering degron motif	0.7582
p.R175Q	TCGA-OL-A5S0	BRCA	TCGA	ADSTS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.R175Q	DO44155	BRCA	ICGC	ADSTS	DEG_SPOP_SBC_1	161:165	Mutation rewiring degron network	0.0556
p.P586H	DO225322	BRCA	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2222
p.V135M	DO222765	COCA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation rewiring degron network	0.0556
p.V135M	DO233944	GACA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation rewiring degron network	0.0556
p.D162N	DO233855	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	161:165	Mutation altering degron motif	0.5821
p.P129T	DO228948	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1944
p.A112E	DO228974	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1944
p.S757R	DO229029	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7427
p.P997Q	DO229022	LICA	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation rewiring degron network	0.2778
p.T125K	DO229027	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.3056
p.T120K	DO229026	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation altering degron motif	0.8417
p.P750T	DO229032	LICA	ICGC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.2222
p.P139T	DO229038	LICA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation rewiring degron network	0.1667
p.P129S	DO50970	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	117:124	Mutation rewiring degron network	0.1944
p.L609M	DO44828	LICA	ICGC	PVTTT	DEG_SPOP_SBC_1	616:620	Mutation rewiring degron network	0.1389
p.E749K	DO45091	LIRI	ICGC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1944
p.T137I	DO220877	MELA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation rewiring degron network	0.1111
p.P586L	DO222702	MELA	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	575:582	Mutation rewiring degron network	0.2222
p.R747C	DO232224	PBCA	ICGC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation rewiring degron network	0.1389
p.R982H	DO229253	THCA	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	987:995	Mutation rewiring degron network	0.1944
p.P147T	DO231467	THCA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation altering degron motif	0.5919
p.S608F	SIDM01169	Ovarian Carcinoma	GDSC	PVTTT	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.5556
p.S608F	ACH-000885	Ovarian Cancer	CCLE	PVTTT	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.5556
p.S608F	TOV-21G	ovary	COSMIC	PVTTT	DEG_SPOP_SBC_1	616:620	Mutation blocking phosphorylation signal	0.5556
p.A52T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation rewiring degron network	0.1944
p.A52T	ACH-000981	Leukemia	CCLE	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation rewiring degron network	0.1944
p.A52T	DND-41	haematopoietic and lymphoid tissue	COSMIC	PRHTPDQS	DEG_SCF_FBW7_1	57:64	Mutation rewiring degron network	0.1944
p.T758I	SIDM00544	Neuroblastoma	GDSC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7078
p.T758I	ACH-001716	Neuroblastoma	CCLE	PVSST	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7078
p.T758I	GOTO	autonomic ganglia	COSMIC	PVSST	DEG_SPOP_SBC_1	754:758	Mutation altering degron motif	0.7078
p.L713P	SIDM00596	Endometrial Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1389
p.L713P	ACH-001517	Endometrial/Uterine Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1389
p.L713P	HEC-1	endometrium	COSMIC	PSSSS	DEG_SPOP_SBC_1	720:724	Mutation rewiring degron network	0.1389
p.M148T	SIDM00971	Breast Carcinoma	GDSC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation altering degron motif	0.7423
p.M148T	ACH-000828	Breast Cancer	CCLE	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation altering degron motif	0.7423
p.M148T	ZR-75-30	breast	COSMIC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	145:151	Mutation altering degron motif	0.7423

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPRIN1

UniProt ID: Q7Z2K8

Entrez ID: 114787

Protein name: G protein-regulated inducer of neurite outgrowth 1 (GRIN1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPRIN1 in