DegronMD

Uniprot ID: Q7Z2K8

Source protein: G protein-regulated inducer of neurite outgrowth 1

Source gene: GPRIN1

Class: DEG_SCF_FBW7_1

Location: 117:124

E3 ligase: FBXW7

DEGRON score: 0.8241

ASA_SCORE: 87.5625

COIL: 0.9396

CONS_SCORE: 0.356

DSS_SCORE: 0.721

HELIX: 0.0207

FCONS_SCORE: 0.9314

RIG_SCORE: 0.5646

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T120K	DO229026	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.8417
p.T125K	DO229027	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.3056
p.G114E	TCGA-97-A4M3	LUAD	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	0.25
p.G114E	DO218937	LUAD	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.25
p.P129T	DO228948	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.1944
p.A112E	DO228974	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.1944
p.P129S	DO50970	LICA	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.1944
p.E130D	TCGA-AX-A2HC	UCEC	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	0.1667
p.E130D	DO41572	UCEC	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.1667
p.L110F	TCGA-B5-A3FA	UCEC	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	0.1389
p.L110F	DO52402	UCEC	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.1389
p.S134F	TCGA-BF-AAP2	SKCM	TCGA	ISGTPEAT	DEG_SCF_FBW7_1	0.0556
p.S134F	DO219466	SKCM	ICGC	ISGTPEAT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SCF_FBW7_1	117:124	ISGTPEAT	FBXW7	0.8241	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons