DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ISGTPEAT
Uniprot ID:
Q7Z2K8
Source protein:
G protein-regulated inducer of neurite outgrowth 1
Source gene:
GPRIN1
Class:
DEG_SCF_FBW7_1
Location:
117:124
E3 ligase:
FBXW7
DEGRON score:
0.8241
ASA_SCORE:
87.5625
COIL:
0.9396
CONS_SCORE:
0.356
DSS_SCORE:
0.721
HELIX:
0.0207
FCONS_SCORE:
0.9314
RIG_SCORE:
0.5646
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G114E
TCGA-97-A4M3
LUAD
TCGA
ISGTPEAT
DEG_SCF_FBW7_1
0.25
p.G114E
DO218937
LUAD
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.25
p.E130D
TCGA-AX-A2HC
UCEC
TCGA
ISGTPEAT
DEG_SCF_FBW7_1
0.1667
p.E130D
DO41572
UCEC
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.1667
p.L110F
TCGA-B5-A3FA
UCEC
TCGA
ISGTPEAT
DEG_SCF_FBW7_1
0.1389
p.L110F
DO52402
UCEC
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.1389
p.S134F
TCGA-BF-AAP2
SKCM
TCGA
ISGTPEAT
DEG_SCF_FBW7_1
0.0556
p.S134F
DO219466
SKCM
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.0556
p.P129T
DO228948
LICA
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.1944
p.A112E
DO228974
LICA
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.1944
p.T125K
DO229027
LICA
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.3056
p.T120K
DO229026
LICA
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.8417
p.P129S
DO50970
LICA
ICGC
ISGTPEAT
DEG_SCF_FBW7_1
0.1944
Drug responses associated with GPRIN1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISGTPEAT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z2K8
G protein-regulated inducer of neurite outgrowth 1
DEG_SCF_FBW7_1
117:124
ISGTPEAT
FBXW7
0.8241
More...