DegronMD

Uniprot ID: Q7Z2K8

Source protein: G protein-regulated inducer of neurite outgrowth 1

Source gene: GPRIN1

Class: DEG_SCF_FBW7_1

Location: 57:64

E3 ligase: FBXW7

DEGRON score: 0.9919

ASA_SCORE: 105.9

COIL: 0.9673

CONS_SCORE: 0.3123

DSS_SCORE: 0.8963

HELIX: 0.0146

FCONS_SCORE: 1.0271

RIG_SCORE: 0.5286

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q49E	TCGA-21-1077	LUSC	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	0.1111
p.Q49E	DO26725	LUSC	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	0.1111
p.Q49K	TCGA-44-6145	LUAD	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	0.1111
p.Q49K	DO25123	LUAD	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	0.1111
p.P61H	TCGA-73-4666	LUAD	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	0.7694
p.P61H	DO26230	LUAD	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	0.7694
p.P61L	TCGA-FS-A1Z0	SKCM	TCGA	PRHTPDQS	DEG_SCF_FBW7_1	0.7582
p.P61L	DO37431	SKCM	ICGC	PRHTPDQS	DEG_SCF_FBW7_1	0.7582
p.A52T	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRHTPDQS	DEG_SCF_FBW7_1	0.1944
p.A52T	ACH-000981	Leukemia	CCLE	PRHTPDQS	DEG_SCF_FBW7_1	0.1944
p.A52T	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PRHTPDQS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SCF_FBW7_1	57:64	PRHTPDQS	FBXW7	0.9919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons