DegronMD

Uniprot ID: Q7Z2K8

Source protein: G protein-regulated inducer of neurite outgrowth 1

Source gene: GPRIN1

Class: LIG_APCC_ABBAyCdc20_2

Location: 145:151

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8493

ASA_SCORE: 99.7714

COIL: 0.8021

CONS_SCORE: 0.3834

DSS_SCORE: 0.6718

HELIX: 0.1664

FCONS_SCORE: 1.035

RIG_SCORE: 0.7252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P147S	TCGA-ER-A19K	SKCM	TCGA	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.5641
p.P147S	DO47672	SKCM	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.5641
p.V135M	DO222765	COCA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V135M	DO233944	GACA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.P139T	DO229038	LICA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.T137I	DO220877	MELA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.1111
p.P147T	DO231467	THCA	ICGC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.5919
p.M148T	SIDM00971	Breast Carcinoma	GDSC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.7423
p.M148T	ACH-000828	Breast Cancer	CCLE	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.7423
p.M148T	ZR-75-30	breast	COSMIC	RNPMFLE	LIG_APCC_ABBAyCdc20_2	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	LIG_APCC_ABBAyCdc20_2	145:151	RNPMFLE	APC,CDC20,FZR1	0.8493	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons