DegronMD

Uniprot ID: Q7Z2K8

Source protein: G protein-regulated inducer of neurite outgrowth 1

Source gene: GPRIN1

Class: DEG_APCC_DBOX_1

Location: 987:995

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8805

ASA_SCORE: 81.9222

COIL: 0.3973

CONS_SCORE: 0.5612

DSS_SCORE: 0.5165

HELIX: 0.578

FCONS_SCORE: 1.1951

RIG_SCORE: 0.7887

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1005T	TCGA-05-4384	LUAD	TCGA	FRALLQSVR	DEG_APCC_DBOX_1	0.0556
p.P1005T	DO23618	LUAD	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	0.0556
p.A989V	TCGA-AP-A1DK	UCEC	TCGA	FRALLQSVR	DEG_APCC_DBOX_1	0.5825
p.A989V	DO42033	UCEC	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	0.5825
p.R998L	TCGA-BR-A4QL	STAD	TCGA	FRALLQSVR	DEG_APCC_DBOX_1	0.25
p.R998L	DO38723	STAD	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	0.25
p.P997Q	DO229022	LICA	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	0.2778
p.R982H	DO229253	THCA	ICGC	FRALLQSVR	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_APCC_DBOX_1	987:995	FRALLQSVR	APC,CDC20,FZR1	0.8805	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons