DegronMD

Uniprot ID: Q7Z2K8

Source protein: G protein-regulated inducer of neurite outgrowth 1

Source gene: GPRIN1

Class: DEG_SCF_FBW7_1

Location: 575:582

E3 ligase: FBXW7

DEGRON score: 0.9912

ASA_SCORE: 98.425

COIL: 0.9644

CONS_SCORE: 0.4224

DSS_SCORE: 0.5249

HELIX: 0.01

FCONS_SCORE: 1.1468

RIG_SCORE: 0.6628

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P586S	TCGA-17-Z058	LUAD	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.2222
p.P586S	TCGA-AP-A1DV	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.2222
p.P586S	DO43186	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.2222
p.S587L	TCGA-AA-3845	COAD	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.1944
p.S587L	TCGA-AX-A2HC	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.1944
p.S587L	DO10020	COAD	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.1944
p.S587L	DO41572	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.1944
p.D591Y	TCGA-AA-A010	COAD	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.0833
p.P584S	TCGA-BS-A0UV	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.2778
p.P584S	DO42793	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.2778
p.P584Q	TCGA-DI-A1BU	UCEC	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.2778
p.P584Q	DO42023	UCEC	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.2778
p.G567V	TCGA-EE-A2GT	SKCM	TCGA	VVSTPGKT	DEG_SCF_FBW7_1	0.1111
p.G567V	DO37946	SKCM	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.1111
p.P586H	DO225322	BRCA	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.2222
p.P586L	DO222702	MELA	ICGC	VVSTPGKT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SCF_FBW7_1	575:582	VVSTPGKT	FBXW7	0.9912	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons