DegronMD

Uniprot ID: Q7Z2K8

Source protein: G protein-regulated inducer of neurite outgrowth 1

Source gene: GPRIN1

Class: DEG_SPOP_SBC_1

Location: 161:165

E3 ligase: SPOP

DEGRON score: 0.9942

ASA_SCORE: 82.36

COIL: 0.9538

CONS_SCORE: 0.625

DSS_SCORE: 0.6813

HELIX: 0.0204

FCONS_SCORE: 1.5547

RIG_SCORE: 0.6042

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R175Q	TCGA-OL-A5S0	BRCA	TCGA	ADSTS	DEG_SPOP_SBC_1	0.0556
p.R175Q	DO44155	BRCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.D162N	DO233855	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.5821

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons