DegronMD

Uniprot ID: Q99684

Source protein: Zinc finger protein Gfi-1

Source gene: GFI1

Class: DEG_SPOP_SBC_1

Location: 38:42

E3 ligase: SPOP

DEGRON score: 0.833

ASA_SCORE: 70.68

COIL: 0.7904

CONS_SCORE: 0.3969

DSS_SCORE: 0.7196

HELIX: 0.123

FCONS_SCORE: 0.9095

RIG_SCORE: 0.5737

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G46V	TCGA-18-3410	LUSC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.2222
p.G46V	DO26456	LUSC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2222
p.R37P	TCGA-44-7662	LUAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.3056
p.R37P	DO23597	LUAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.G46W	TCGA-50-7109	LUAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.2222
p.G46W	DO24487	LUAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2222
p.S40I	TCGA-B5-A3FC	UCEC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.8453
p.S40I	DO41871	UCEC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.8453
p.S40G	TCGA-BQ-7048	KIRP	TCGA	ADSTS	DEG_SPOP_SBC_1	0.8104
p.S40G	DO20936	KIRP	ICGC	ADSTS	DEG_SPOP_SBC_1	0.8104
p.A49V	TCGA-CV-6938	HNSC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1389
p.A49V	DO14462	HNSC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.E30D	TCGA-E6-A1LX	UCEC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1111
p.E30D	DO41020	UCEC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1111
p.R37L	TCGA-ER-A19P	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	0.3056
p.R37L	DO47623	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.R28C	TCGA-FW-A3R5	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	0.0556
p.R28C	DO37406	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.R37Q	DO233653	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.A34E	DO229019	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2222
p.A38T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	0.7139
p.A38T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	0.7139
p.A38T	ACH-000995	Leukemia	CCLE	ADSTS	DEG_SPOP_SBC_1	0.7139
p.A38T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.7139
p.S40N	SIDM00534	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.818
p.S40N	ACH-000986	Colon/Colorectal Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.818
p.S40N	HT-115	large_intestine	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.818

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSTS

Degron related mutations and impact score

Drug responses associated with GFI1 mutations

All proteins holding degron of ADSTS