DegronMD

Uniprot ID: Q9C0D7

Source protein: Probable ribonuclease ZC3H12C

Source gene: ZC3H12C

Class: DEG_SPOP_SBC_1

Location: 476:480

E3 ligase: SPOP

DEGRON score: 0.9991

ASA_SCORE: 77.88

COIL: 0.824

CONS_SCORE: 0.3894

DSS_SCORE: 0.5998

HELIX: 0.17

FCONS_SCORE: 1.0011

RIG_SCORE: 0.6624

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P471H	TCGA-DA-A1IB	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	0.1944
p.S478I	TCGA-HU-A4GN	STAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.8453
p.D477N	TCGA-JW-A5VL	CESC	TCGA	ADSTS	DEG_SPOP_SBC_1	0.5821
p.T466I	DO22237	LGG	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.T466I	HEC-1	endometrium	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.A477S	DO229028	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.7588
p.R485L	DO229037	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.A487S	DO229041	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1389
p.T466A	DO42129	UCEC	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.V466M	ACH-002256	Leukemia	CCLE	ADSTS	DEG_SPOP_SBC_1	0.1667
p.V466M	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.E473V	huH-1	liver	COSMIC	ADSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons