DegronMD

Uniprot ID: O60320

Source protein: Protein FAM189A1

Source gene: FAM189A1

Class: DEG_SPOP_SBC_1

Location: 337:341

E3 ligase: SPOP

DEGRON score: 0.919

ASA_SCORE: 65.04

COIL: 0.7678

CONS_SCORE: 0.3473

DSS_SCORE: 0.6315

HELIX: 0.1716

FCONS_SCORE: 1.009

RIG_SCORE: 0.6905

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E346K	DO222492	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.E346K	SIDM01945	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.S339I	DO233885	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.7341
p.L342F	ACH-000410	Bone Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.3056
p.D338N	ACH-000594	Lung Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.5821
p.P336L	ACH-001389	Breast Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons