DegronMD

Uniprot ID: Q27J81

Source protein: Inverted formin-2

Source gene: INF2

Class: DEG_SPOP_SBC_1

Location: 1145:1149

E3 ligase: SPOP

DEGRON score: 0.9983

ASA_SCORE: 73.7

COIL: 0.7628

CONS_SCORE: 0.3008

DSS_SCORE: 0.6297

HELIX: 0.2088

FCONS_SCORE: 0.9899

RIG_SCORE: 0.6467

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1144K	TCGA-A6-6781	COAD	TCGA	ADSTS	DEG_SPOP_SBC_1	0.3056
p.E1144K	DO8447	COAD	ICGC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.S1136F	TCGA-EB-A431	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	0.5278
p.S1136F	TCGA-W3-AA1V	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	0.5278
p.S1136F	DO37671	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	0.5278
p.S1136F	DO51276	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	0.5278
p.S1158R	DO230343	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.5278
p.T1135M	DO229003	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	DO229005	COCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00434	Plasma Cell Myeloma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00353	Other Sarcomas	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00338	Acute Myeloid Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01020	Plasma Cell Myeloma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00577	Neuroblastoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00547	Non-Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00600	Thyroid Gland Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00193	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01145	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00571	Pancreatic Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00530	Esophageal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00238	Ovarian Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00568	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00562	Breast Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00383	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00817	Kidney Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00054	Pancreatic Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00024	Non-Cancerous	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00365	Small Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00612	Glioma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00970	Bladder Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00618	Hepatocellular Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00561	Other Blood Cancers	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00289	B-Lymphoblastic Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00503	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00604	Oral Cavity Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01609	Endometrial Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01464	Pancreatic Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00500	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01588	Endometrial Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM00162	Biliary Tract Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.T1135M	SIDM01343	Gastric Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.0556
p.G1151V	DO229019	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2778
p.A1143D	DO50672	ORCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.2778
p.A1155V	DO219881	SKCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.1667
p.E1150G	DO219881	SKCA	ICGC	ADSTS	DEG_SPOP_SBC_1	0.3056
p.V1140I	SIDM01619	Endometrial Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	0.1944
p.V1140I	ACH-000984	Endometrial/Uterine Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2795:2799	ADSTS	SPOP	0.9671	More...
Q27J81	Inverted formin-2	DEG_SPOP_SBC_1	1145:1149	ADSTS	SPOP	0.9983	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	515:519	ADSTS	SPOP	0.9834	More...
Q6VMQ6	Activating transcription factor 7-interacting protein 1	DEG_SPOP_SBC_1	949:953	ADSTS	SPOP	0.8767	More...
Q99684	Zinc finger protein Gfi-1	DEG_SPOP_SBC_1	38:42	ADSTS	SPOP	0.833	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1085:1089	ADSTS	SPOP	0.9906	More...
Q7Z2K8	G protein-regulated inducer of neurite outgrowth 1	DEG_SPOP_SBC_1	161:165	ADSTS	SPOP	0.9942	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	476:480	ADSTS	SPOP	0.9991	More...
O60320	Protein FAM189A1	DEG_SPOP_SBC_1	337:341	ADSTS	SPOP	0.919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ADSTS

Degron related mutations and impact score

Drug responses associated with INF2 mutations

All proteins holding degron of ADSTS