DegronMD - Q99684(GFI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G46V	TCGA-18-3410	LUSC	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2222
p.G46V	DO26456	LUSC	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2222
p.R37P	TCGA-44-7662	LUAD	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.3056
p.R37P	DO23597	LUAD	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.3056
p.G46W	TCGA-50-7109	LUAD	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2222
p.G46W	DO24487	LUAD	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2222
p.S40I	TCGA-B5-A3FC	UCEC	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.8453
p.S40I	DO41871	UCEC	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.8453
p.S40G	TCGA-BQ-7048	KIRP	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.8104
p.S40G	DO20936	KIRP	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.8104
p.A49V	TCGA-CV-6938	HNSC	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1389
p.A49V	DO14462	HNSC	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1389
p.E30D	TCGA-E6-A1LX	UCEC	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.E30D	DO41020	UCEC	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.1111
p.R37L	TCGA-ER-A19P	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.3056
p.R37L	DO47623	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.3056
p.R28C	TCGA-FW-A3R5	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0556
p.R28C	DO37406	SKCM	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.0556
p.R37Q	DO233653	GACA	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.3056
p.A34E	DO229019	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation rewiring degron network	0.2222
p.A149T	DO42673	UCEC	ICGC	LGLFCE	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.2778
p.A149T	SIDM01051	Ovarian Carcinoma	GDSC	LGLFCE	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.2778
p.A149T	ACH-000936	Ovarian Cancer	CCLE	LGLFCE	LIG_APCC_ABBA_1	151:156	Mutation rewiring degron network	0.2778
p.A38T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7139
p.A38T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7139
p.A38T	ACH-000995	Leukemia	CCLE	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7139
p.A38T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.7139
p.S40N	SIDM00534	Colorectal Carcinoma	GDSC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.818
p.S40N	ACH-000986	Colon/Colorectal Cancer	CCLE	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.818
p.S40N	HT-115	large intestine	COSMIC	ADSTS	DEG_SPOP_SBC_1	38:42	Mutation altering degron motif	0.818

Kaplan plot for GFI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GFI1

UniProt ID: Q99684

Entrez ID: 2672

Protein name: Zinc finger protein Gfi-1 (Growth factor independent protein 1) (Zinc finger protein 163)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GFI1 in