DegronMD - Q9C0D7(ZC3H12C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P525L	TCGA-55-6642	LUAD	TCGA	PATST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7582
p.T527A	TCGA-56-A49D	LUSC	TCGA	PATST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7139
p.F31L	TCGA-92-8063	LUSC	TCGA	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.I619T	TCGA-AP-A056	UCEC	TCGA	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.3056
p.Q498H	TCGA-BR-8680	STAD	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.647
p.P471H	TCGA-DA-A1IB	SKCM	TCGA	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1944
p.T497I	TCGA-DU-6392	LGG	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.5966
p.T497I	SIDM00596	Endometrial Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.5966
p.T497I	HEC-1	endometrium	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.5966
p.D625N	TCGA-DX-A1KW	SARC	TCGA	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.1389
p.R28C	TCGA-EO-A22R	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.3056
p.T497A	TCGA-EY-A1GD	UCEC	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.6028
p.P532L	TCGA-FS-A1ZZ	SKCM	TCGA	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation altering degron motif	0.7582
p.S494N	TCGA-G4-6586	COAD	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.2778
p.S478I	TCGA-HU-A4GN	STAD	TCGA	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation altering degron motif	0.8453
p.D477N	TCGA-JW-A5VL	CESC	TCGA	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation altering degron motif	0.5821
p.L34V	TCGA-L5-A8NE	ESCA	TCGA	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.S624C	TCGA-ZF-A9RG	BLCA	TCGA	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.1667
p.S625C	DO219076	BLCA	ICGC	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.1389
p.P621S	DO1255	BRCA	ICGC	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.25
p.R611H	DO6422	CLLE	ICGC	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.1944
p.L504P	DO234234	ESAD	ICGC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0556
p.L504P	DO234234	ESAD	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.2778
p.D20G	DO233766	GACA	ICGC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.T466I	DO22237	LGG	ICGC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation substituting flanking lysine	0.1667
p.T466I	HEC-1	endometrium	COSMIC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation substituting flanking lysine	0.1667
p.Q534E	DO228933	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation altering degron motif	0.6744
p.A499S	DO228971	LICA	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.7588
p.A477S	DO229028	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation altering degron motif	0.7588
p.R485L	DO229037	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1944
p.R523I	DO229037	LICA	ICGC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.2778
p.R523I	DO229037	LICA	ICGC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.2778
p.R523I	DO229037	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.0833
p.A487S	DO229041	LICA	ICGC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.1389
p.A487S	DO229041	LICA	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.0833
p.P544S	DO229050	LICA	ICGC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.1111
p.W29L	DO218944	LUAD	ICGC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2778
p.P494L	DO23622	LUAD	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.2778
p.H516D	DO24950	LUAD	ICGC	ETRSVPSL	DEG_COP1_1	514:521	Mutation altering degron motif	0.7688
p.F32L	DO26941	LUSC	ICGC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.T528A	DO45475	LUSC	ICGC	PATST	DEG_SPOP_SBC_1	525:529	Mutation altering degron motif	0.7139
p.P501L	DO37412	SKCM	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.7582
p.P519H	DO47849	STAD	ICGC	ETRSVPSL	DEG_COP1_1	514:521	Mutation altering degron motif	0.7694
p.Q499H	DO47769	STAD	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.7582
p.T466A	DO42129	UCEC	ICGC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation substituting flanking lysine	0.1667
p.L14I	DO43306	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.0833
p.R29C	DO42713	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2778
p.P543T	DO41361	UCEC	ICGC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.1389
p.I620T	DO43971	UCEC	ICGC	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.2778
p.E504V	SIDM00586	Hepatocellular Carcinoma	GDSC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0556
p.E504V	SIDM00586	Hepatocellular Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.2778
p.E504V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0556
p.E504V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.2778
p.E504V	SIDM00240	Cervical Carcinoma	GDSC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0556
p.E504V	SIDM00240	Cervical Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.2778
p.E504V	huH-1	liver	COSMIC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0556
p.E504V	huH-1	liver	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.2778
p.S537P	SIDM00845	Burkitt's Lymphoma	GDSC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.S537P	SIDM00845	Burkitt's Lymphoma	GDSC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.S537P	SIDM00035	Thyroid Gland Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.S537P	SIDM00035	Thyroid Gland Carcinoma	GDSC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.S537P	SIDM00461	Acute Myeloid Leukemia	GDSC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.S537P	SIDM00461	Acute Myeloid Leukemia	GDSC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.S537P	SIDM01519	Head and Neck Carcinoma	GDSC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.S537P	SIDM01519	Head and Neck Carcinoma	GDSC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.S537P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.S537P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.S537P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.S537P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.Q15H	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.Q15H	SW900	lung	COSMIC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.N30S	SIDM01335	Kidney Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.N30S	SIDM01394	Kidney Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.T536A	SIDM01611	Endometrial Carcinoma	GDSC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation altering degron motif	0.7139
p.S538P	ACH-000037	Sarcoma	CCLE	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0833
p.S538P	ACH-000037	Sarcoma	CCLE	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.S538P	ACH-000786	Lymphoma	CCLE	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0833
p.S538P	ACH-000786	Lymphoma	CCLE	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.S538P	ACH-000992	Head and Neck Cancer	CCLE	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0833
p.S538P	ACH-000992	Head and Neck Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.S538P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0833
p.S538P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.S538P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.0833
p.S538P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.Q16H	ACH-000669	Lung Cancer	CCLE	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.Q16H	SW900	lung	COSMIC	VESST	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.T498I	ACH-000941	Endometrial/Uterine Cancer	CCLE	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.7078
p.T498I	ACH-000954	Endometrial/Uterine Cancer	CCLE	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.7078
p.T498I	ACH-001517	Endometrial/Uterine Cancer	CCLE	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.7078
p.T498I	HEC-1	endometrium	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation altering degron motif	0.7078
p.T537A	ACH-000996	Endometrial/Uterine Cancer	CCLE	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.1111
p.T537A	ACH-000996	Endometrial/Uterine Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.3056
p.D626N	ACH-001411	Bladder Cancer	CCLE	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.1111
p.T536S	ACH-001558	Lung Cancer	CCLE	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation altering degron motif	0.6005
p.V466M	ACH-002256	Leukemia	CCLE	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation substituting flanking lysine	0.1667
p.V466M	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation substituting flanking lysine	0.1667
p.S530P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0833
p.S530P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.S530P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.S530P	DND-41	haematopoietic and lymphoid tissue	COSMIC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0833
p.S530P	DND-41	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.S530P	DND-41	haematopoietic and lymphoid tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.S530P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0833
p.S530P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	525:529	Mutation rewiring degron network	0.3056
p.S530P	Daudi	haematopoietic and lymphoid tissue	COSMIC	PQSTT	DEG_SPOP_SBC_1	532:536	Mutation rewiring degron network	0.2778
p.S619C	NCI-H2110	lung	COSMIC	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.3056
p.S506P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ETRSVPSL	DEG_COP1_1	514:521	Mutation substituting flanking lysine	0.2222
p.S506P	Daudi	haematopoietic and lymphoid tissue	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation substituting flanking lysine	0.3333
p.S506P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ETRSVPSL	DEG_COP1_1	514:521	Mutation substituting flanking lysine	0.2222
p.S506P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation substituting flanking lysine	0.3333
p.E505V	huH-1	liver	COSMIC	ETRSVPSL	DEG_COP1_1	514:521	Mutation rewiring degron network	0.0833
p.E505V	huH-1	liver	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	496:502	Mutation rewiring degron network	0.25
p.G611C	HCT-15	large intestine	COSMIC	DYR	CBL_MET	616:618	Mutation rewiring degron network	0.1944
p.E473V	huH-1	liver	COSMIC	ADSTS	DEG_SPOP_SBC_1	476:480	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3H12C

UniProt ID: Q9C0D7

Entrez ID: 85463

Protein name: Probable ribonuclease ZC3H12C (EC 3.1.-.-) (MCP-induced protein 3) (Zinc finger CCCH domain-containing protein 12C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3H12C in