DegronMD

Uniprot ID: Q9C0D7

Source protein: Probable ribonuclease ZC3H12C

Source gene: ZC3H12C

Class: LIG_APCC_ABBAyCdc20_2

Location: 496:502

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7122

ASA_SCORE: 92.9714

COIL: 0.6189

CONS_SCORE: 0.3971

DSS_SCORE: 0.6045

HELIX: 0.3026

FCONS_SCORE: 1.0201

RIG_SCORE: 0.7746

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q498H	TCGA-BR-8680	STAD	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.647
p.T497I	TCGA-DU-6392	LGG	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.5966
p.T497I	SIDM00596	Endometrial Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.5966
p.T497I	HEC-1	endometrium	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.5966
p.T497A	TCGA-EY-A1GD	UCEC	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.6028
p.S494N	TCGA-G4-6586	COAD	TCGA	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L504P	DO234234	ESAD	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.A499S	DO228971	LICA	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.7588
p.A487S	DO229041	LICA	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.0833
p.P494L	DO23622	LUAD	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.P501L	DO37412	SKCM	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.7582
p.Q499H	DO47769	STAD	ICGC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.7582
p.E504V	SIDM00586	Hepatocellular Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E504V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E504V	SIDM00240	Cervical Carcinoma	GDSC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.E504V	huH-1	liver	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T498I	ACH-000941	Endometrial/Uterine Cancer	CCLE	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.T498I	ACH-000954	Endometrial/Uterine Cancer	CCLE	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.T498I	ACH-001517	Endometrial/Uterine Cancer	CCLE	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.T498I	HEC-1	endometrium	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.7078
p.S506P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.3333
p.S506P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.3333
p.E505V	huH-1	liver	COSMIC	RTQVYQD	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D7	Probable ribonuclease ZC3H12C	LIG_APCC_ABBAyCdc20_2	496:502	RTQVYQD	APC,CDC20,FZR1	0.7122	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RTQVYQD

Degron related mutations and impact score

Drug responses associated with ZC3H12C mutations

All proteins holding degron of RTQVYQD