DegronMD

Uniprot ID: Q9C0D7

Source protein: Probable ribonuclease ZC3H12C

Source gene: ZC3H12C

Class: DEG_COP1_1

Location: 514:521

E3 ligase: COP1

DEGRON score: 0.849

ASA_SCORE: 104.625

COIL: 0.917

CONS_SCORE: 0.3735

DSS_SCORE: 0.4982

HELIX: 0.0505

FCONS_SCORE: 0.9336

RIG_SCORE: 0.7318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L504P	DO234234	ESAD	ICGC	ETRSVPSL	DEG_COP1_1	0.0556
p.R523I	DO229037	LICA	ICGC	ETRSVPSL	DEG_COP1_1	0.2778
p.H516D	DO24950	LUAD	ICGC	ETRSVPSL	DEG_COP1_1	0.7688
p.P519H	DO47849	STAD	ICGC	ETRSVPSL	DEG_COP1_1	0.7694
p.E504V	SIDM00586	Hepatocellular Carcinoma	GDSC	ETRSVPSL	DEG_COP1_1	0.0556
p.E504V	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	ETRSVPSL	DEG_COP1_1	0.0556
p.E504V	SIDM00240	Cervical Carcinoma	GDSC	ETRSVPSL	DEG_COP1_1	0.0556
p.E504V	huH-1	liver	COSMIC	ETRSVPSL	DEG_COP1_1	0.0556
p.S530P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ETRSVPSL	DEG_COP1_1	0.0833
p.S530P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ETRSVPSL	DEG_COP1_1	0.0833
p.S530P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ETRSVPSL	DEG_COP1_1	0.0833
p.S506P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ETRSVPSL	DEG_COP1_1	0.2222
p.S506P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ETRSVPSL	DEG_COP1_1	0.2222
p.E505V	huH-1	liver	COSMIC	ETRSVPSL	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_COP1_1	514:521	ETRSVPSL	COP1	0.849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons