DegronMD

Uniprot ID: Q9C0D7

Source protein: Probable ribonuclease ZC3H12C

Source gene: ZC3H12C

Class: DEG_SPOP_SBC_1

Location: 23:27

E3 ligase: SPOP

DEGRON score: 0.9811

ASA_SCORE: 71.28

COIL: 0.6836

CONS_SCORE: 0.402

DSS_SCORE: 0.433

HELIX: 0.256

FCONS_SCORE: 1.1051

RIG_SCORE: 0.728

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F31L	TCGA-92-8063	LUSC	TCGA	VESST	DEG_SPOP_SBC_1	0.2222
p.R28C	TCGA-EO-A22R	UCEC	TCGA	VESST	DEG_SPOP_SBC_1	0.3056
p.L34V	TCGA-L5-A8NE	ESCA	TCGA	VESST	DEG_SPOP_SBC_1	0.1389
p.D20G	DO233766	GACA	ICGC	VESST	DEG_SPOP_SBC_1	0.25
p.W29L	DO218944	LUAD	ICGC	VESST	DEG_SPOP_SBC_1	0.2778
p.F32L	DO26941	LUSC	ICGC	VESST	DEG_SPOP_SBC_1	0.1944
p.L14I	DO43306	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	0.0833
p.R29C	DO42713	UCEC	ICGC	VESST	DEG_SPOP_SBC_1	0.2778
p.Q15H	SIDM01158	Squamous Cell Lung Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	0.1111
p.Q15H	SW900	lung	COSMIC	VESST	DEG_SPOP_SBC_1	0.1111
p.N30S	SIDM01335	Kidney Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	0.25
p.N30S	SIDM01394	Kidney Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	0.25
p.Q16H	ACH-000669	Lung Cancer	CCLE	VESST	DEG_SPOP_SBC_1	0.1389
p.Q16H	SW900	lung	COSMIC	VESST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	318:322	VESST	SPOP	0.9996	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	675:679	VESST	SPOP	0.842	More...
Q6R327	Rapamycin-insensitive companion of mTOR	DEG_SPOP_SBC_1	1205:1209	VESST	SPOP	0.9971	More...
Q6ZTR5	Cilia- and flagella-associated protein 47	DEG_SPOP_SBC_1	2013:2017	VESST	SPOP	0.7453	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	581:585	VESST	SPOP	0.9759	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	23:27	VESST	SPOP	0.9811	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	346:350	VESST	SPOP	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons