DegronMD

Uniprot ID: Q9ULI3

Source protein: Protein HEG homolog 1

Source gene: HEG1

Class: DEG_SPOP_SBC_1

Location: 581:585

E3 ligase: SPOP

DEGRON score: 0.9759

ASA_SCORE: 93.38

COIL: 0.9132

CONS_SCORE: 0.7324

DSS_SCORE: 0.3247

HELIX: 0.0342

FCONS_SCORE: 1.7721

RIG_SCORE: 0.7375

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S584A	TCGA-DX-AB2W	SARC	TCGA	VESST	DEG_SPOP_SBC_1	0.7588
p.S584A	DO220095	SARC	ICGC	VESST	DEG_SPOP_SBC_1	0.7588
p.S594L	DO218173	BRCA	ICGC	VESST	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O76039	Cyclin-dependent kinase-like 5	DEG_SPOP_SBC_1	318:322	VESST	SPOP	0.9996	More...
P49321	Nuclear autoantigenic sperm protein	DEG_SPOP_SBC_1	675:679	VESST	SPOP	0.842	More...
Q6R327	Rapamycin-insensitive companion of mTOR	DEG_SPOP_SBC_1	1205:1209	VESST	SPOP	0.9971	More...
Q6ZTR5	Cilia- and flagella-associated protein 47	DEG_SPOP_SBC_1	2013:2017	VESST	SPOP	0.7453	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	581:585	VESST	SPOP	0.9759	More...
Q9C0D7	Probable ribonuclease ZC3H12C	DEG_SPOP_SBC_1	23:27	VESST	SPOP	0.9811	More...
Q9H8J5	MANSC domain-containing protein 1	DEG_SPOP_SBC_1	346:350	VESST	SPOP	0.9938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons