DegronMD - P49321(NASP)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D483H	TCGA-DD-AAC8	LIHC	TCGA	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation rewiring degron network	0.3056
p.D483H	DO52193	LIHC	ICGC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation rewiring degron network	0.3056
p.S480L	TCGA-E2-A15S	BRCA	TCGA	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	DO5597	BRCA	ICGC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	SIDM00580	Acute Myeloid Leukemia	GDSC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	ACH-000168	Leukemia	CCLE	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	ACH-000563	Lung Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	ACH-002263	Esophageal Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	ACH-002785	Unknown	CCLE	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	EBC-1	lung	COSMIC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	KYSE-220	oesophagus	COSMIC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.S480L	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667
p.L674M	TCGA-EE-A17Z	SKCM	TCGA	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.3056
p.L674M	DO37921	SKCM	ICGC	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.3056
p.P27A	TCGA-EE-A2MU	SKCM	TCGA	APSTS	DEG_SPOP_SBC_1	26:30	Mutation altering degron motif	0.6392
p.P27A	DO37436	SKCM	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation altering degron motif	0.6392
p.D23H	TCGA-RD-A8N6	STAD	TCGA	APSTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.25
p.D23H	DO50140	STAD	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.25
p.S20F	DO223089	ESCA	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation substituting flanking lysine	0.2778
p.G685C	DO229019	LICA	ICGC	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1667
p.V675L	DO229022	LICA	ICGC	VESST	DEG_SPOP_SBC_1	675:679	Mutation altering degron motif	0.6765
p.A31S	DO229022	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.3056
p.A26S	DO229037	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation altering degron motif	0.7588
p.V21F	DO229041	LICA	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1944
p.A666S	DO229045	LICA	ICGC	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.0833
p.D19Y	DO45097	LIRI	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1389
p.E478D	DO233293	NACA	ICGC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation rewiring degron network	0.1667
p.V21A	DO41584	UCEC	ICGC	APSTS	DEG_SPOP_SBC_1	26:30	Mutation rewiring degron network	0.1944
p.P684S	SIDM00690	Head and Neck Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.P684S	ACH-002251	Head and Neck Cancer	CCLE	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.P684S	JHU-029	upper aerodigestive tract	COSMIC	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1944
p.A669T	SIDM00282	Colorectal Carcinoma	GDSC	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1667
p.A669T	ACH-000998	Colon/Colorectal Cancer	CCLE	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1667
p.A669T	CW-2	large intestine	COSMIC	VESST	DEG_SPOP_SBC_1	675:679	Mutation rewiring degron network	0.1667
p.E486D	SIDM00118	Colorectal Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation altering degron motif	0.6758
p.E486D	ACH-001081	Colon/Colorectal Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation altering degron motif	0.6758
p.E486D	HCC2998	large intestine	COSMIC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation altering degron motif	0.6758
p.A480T	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	DKEND	DEG_APCC_KENBOX_2	484:488	Mutation blocking phosphorylation signal	0.6667

Kaplan plot for NASP in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NASP

UniProt ID: P49321

Entrez ID: 4678

Protein name: Nuclear autoantigenic sperm protein (NASP)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NASP in