DegronMD

Uniprot ID: P49321

Source protein: Nuclear autoantigenic sperm protein

Source gene: NASP

Class: DEG_APCC_KENBOX_2

Location: 484:488

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9718

ASA_SCORE: 113.6

COIL: 0.6928

CONS_SCORE: 0.4029

DSS_SCORE: 0.8919

HELIX: 0.296

FCONS_SCORE: 1.1615

RIG_SCORE: 0.5919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D483H	TCGA-DD-AAC8	LIHC	TCGA	DKEND	DEG_APCC_KENBOX_2	0.3056
p.D483H	DO52193	LIHC	ICGC	DKEND	DEG_APCC_KENBOX_2	0.3056
p.S480L	TCGA-E2-A15S	BRCA	TCGA	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	DO5597	BRCA	ICGC	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	SIDM00580	Acute Myeloid Leukemia	GDSC	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	ACH-000168	Leukemia	CCLE	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	ACH-000563	Lung Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	ACH-002263	Esophageal Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	ACH-002785	Unknown	CCLE	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	EBC-1	lung	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	KYSE-220	oesophagus	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.6667
p.S480L	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.6667
p.E478D	DO233293	NACA	ICGC	DKEND	DEG_APCC_KENBOX_2	0.1667
p.E486D	SIDM00118	Colorectal Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	0.6758
p.E486D	ACH-001081	Colon/Colorectal Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	0.6758
p.E486D	HCC2998	large_intestine	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.6758
p.A480T	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30305	M-phase inducer phosphatase 2	DEG_APCC_KENBOX_2	191:195	DKEND	APC,CDC20,FZR1	0.9928	More...
P49321	Nuclear autoantigenic sperm protein	DEG_APCC_KENBOX_2	484:488	DKEND	APC,CDC20,FZR1	0.9718	More...
Q9BZF1	Oxysterol-binding protein-related protein 8	DEG_APCC_KENBOX_2	332:336	DKEND	APC,CDC20,FZR1	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons