DegronMD

Uniprot ID: Q9BZF1

Source protein: Oxysterol-binding protein-related protein 8

Source gene: OSBPL8

Class: DEG_APCC_KENBOX_2

Location: 332:336

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9813

ASA_SCORE: 103.78

COIL: 0.7922

CONS_SCORE: 0.3327

DSS_SCORE: 0.815

HELIX: 0.1788

FCONS_SCORE: 1.062

RIG_SCORE: 0.5733

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D343H	TCGA-4Z-AA7M	BLCA	TCGA	DKEND	DEG_APCC_KENBOX_2	0.1389
p.D343H	DO218976	BLCA	ICGC	DKEND	DEG_APCC_KENBOX_2	0.1389
p.D325G	DO220891	MELA	ICGC	DKEND	DEG_APCC_KENBOX_2	0.1389
p.D323N	SIDM00789	Colorectal Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	0.0833
p.D323N	ACH-000997	Colon/Colorectal Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	0.0833
p.D323N	ACH-001061	Colon/Colorectal Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	0.0833
p.D323N	HCT-15	large_intestine	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30305	M-phase inducer phosphatase 2	DEG_APCC_KENBOX_2	191:195	DKEND	APC,CDC20,FZR1	0.9928	More...
P49321	Nuclear autoantigenic sperm protein	DEG_APCC_KENBOX_2	484:488	DKEND	APC,CDC20,FZR1	0.9718	More...
Q9BZF1	Oxysterol-binding protein-related protein 8	DEG_APCC_KENBOX_2	332:336	DKEND	APC,CDC20,FZR1	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons