DegronMD

Uniprot ID: P30305

Source protein: M-phase inducer phosphatase 2

Source gene: CDC25B

Class: DEG_APCC_KENBOX_2

Location: 191:195

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9928

ASA_SCORE: 103.1

COIL: 0.819

CONS_SCORE: 0.2558

DSS_SCORE: 0.578

HELIX: 0.1442

FCONS_SCORE: 0.9007

RIG_SCORE: 0.6328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E193D	TCGA-2W-A8YY	CESC	TCGA	DKEND	DEG_APCC_KENBOX_2	0.6758
p.D191H	TCGA-98-A53I	LUSC	TCGA	DKEND	DEG_APCC_KENBOX_2	0.6577
p.E198Q	DO219032	BLCA	ICGC	DKEND	DEG_APCC_KENBOX_2	0.25
p.D204H	DO49976	CESC	ICGC	DKEND	DEG_APCC_KENBOX_2	0.5278
p.T195S	DO234330	ESAD	ICGC	DKEND	DEG_APCC_KENBOX_2	0.7116
p.V181M	DO220252	SARC	ICGC	DKEND	DEG_APCC_KENBOX_2	0.0556
p.P205L	SIDM00999	Bladder Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	0.0556
p.P205L	ACH-000973	Bladder Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	0.0556
p.P205L	639-V	urinary_tract	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.0556
p.E193Q	SIDM00381	Cervical Carcinoma	GDSC	DKEND	DEG_APCC_KENBOX_2	0.6744
p.E193Q	ACH-002020	Cervical Cancer	CCLE	DKEND	DEG_APCC_KENBOX_2	0.6744
p.E193Q	SKG-IIIa	cervix	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.6744
p.P191L	639-V	urinary_tract	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.7582
p.E202K	BT-474	breast	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.1389
p.W203S	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.1111
p.F192L	NUGC-3	stomach	COSMIC	DKEND	DEG_APCC_KENBOX_2	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P30305	M-phase inducer phosphatase 2	DEG_APCC_KENBOX_2	191:195	DKEND	APC,CDC20,FZR1	0.9928	More...
P49321	Nuclear autoantigenic sperm protein	DEG_APCC_KENBOX_2	484:488	DKEND	APC,CDC20,FZR1	0.9718	More...
Q9BZF1	Oxysterol-binding protein-related protein 8	DEG_APCC_KENBOX_2	332:336	DKEND	APC,CDC20,FZR1	0.9813	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons