DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VESST
Uniprot ID:
P49321
Source protein:
Nuclear autoantigenic sperm protein
Source gene:
NASP
Class:
DEG_SPOP_SBC_1
Location:
675:679
E3 ligase:
SPOP
DEGRON score:
0.842
ASA_SCORE:
94.82
COIL:
0.6918
CONS_SCORE:
0.3342
DSS_SCORE:
0.4107
HELIX:
0.2834
FCONS_SCORE:
0.9677
RIG_SCORE:
0.7087
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L674M
TCGA-EE-A17Z
SKCM
TCGA
VESST
DEG_SPOP_SBC_1
0.3056
p.L674M
DO37921
SKCM
ICGC
VESST
DEG_SPOP_SBC_1
0.3056
p.G685C
DO229019
LICA
ICGC
VESST
DEG_SPOP_SBC_1
0.1667
p.V675L
DO229022
LICA
ICGC
VESST
DEG_SPOP_SBC_1
0.6765
p.A666S
DO229045
LICA
ICGC
VESST
DEG_SPOP_SBC_1
0.0833
p.P684S
SIDM00690
Head and Neck Carcinoma
GDSC
VESST
DEG_SPOP_SBC_1
0.1944
p.P684S
ACH-002251
Head and Neck Cancer
CCLE
VESST
DEG_SPOP_SBC_1
0.1944
p.P684S
JHU-029
upper_aerodigestive_tract
COSMIC
VESST
DEG_SPOP_SBC_1
0.1944
p.A669T
SIDM00282
Colorectal Carcinoma
GDSC
VESST
DEG_SPOP_SBC_1
0.1667
p.A669T
ACH-000998
Colon/Colorectal Cancer
CCLE
VESST
DEG_SPOP_SBC_1
0.1667
p.A669T
CW-2
large_intestine
COSMIC
VESST
DEG_SPOP_SBC_1
0.1667
Drug responses associated with NASP mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VESST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O76039
Cyclin-dependent kinase-like 5
DEG_SPOP_SBC_1
318:322
VESST
SPOP
0.9996
More...
P49321
Nuclear autoantigenic sperm protein
DEG_SPOP_SBC_1
675:679
VESST
SPOP
0.842
More...
Q6R327
Rapamycin-insensitive companion of mTOR
DEG_SPOP_SBC_1
1205:1209
VESST
SPOP
0.9971
More...
Q6ZTR5
Cilia- and flagella-associated protein 47
DEG_SPOP_SBC_1
2013:2017
VESST
SPOP
0.7453
More...
Q9ULI3
Protein HEG homolog 1
DEG_SPOP_SBC_1
581:585
VESST
SPOP
0.9759
More...
Q9C0D7
Probable ribonuclease ZC3H12C
DEG_SPOP_SBC_1
23:27
VESST
SPOP
0.9811
More...
Q9H8J5
MANSC domain-containing protein 1
DEG_SPOP_SBC_1
346:350
VESST
SPOP
0.9938
More...