DegronMD - Q9ULI3(HEG1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S377F	TCGA-60-2704	LUSC	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1389
p.S377F	DO26555	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1389
p.D1289Y	TCGA-60-2723	LUSC	TCGA	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.25
p.D1289Y	DO27152	LUSC	ICGC	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.25
p.G1364R	TCGA-61-2018	OV	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.G1364R	TCGA-96-8170	LUSC	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.G1364R	TCGA-VQ-A8PT	STAD	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.G1364R	DO27691	LUSC	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.G1364R	DO29218	OV	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.G1364R	DO51776	STAD	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.G1364R	SIDM01617	Endometrial Carcinoma	GDSC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.G1364R	ACH-000994	Endometrial/Uterine Cancer	CCLE	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0556
p.A984T	TCGA-A5-A0G1	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0556
p.A984T	DO42472	UCEC	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0556
p.R1343Q	TCGA-AG-3892	READ	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	TCGA-AP-A056	UCEC	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	TCGA-EO-A3AY	UCEC	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	TCGA-EO-A3B0	UCEC	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	DO36394	READ	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	DO219773	UCEC	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	DO43202	UCEC	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	DO43971	UCEC	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	SIDM00545	Melanoma	GDSC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	ACH-000987	Skin Cancer	CCLE	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R1343Q	Mewo	skin	COSMIC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.R364K	TCGA-AN-A046	BRCA	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.2778
p.R364K	DO1285	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.2778
p.R1303H	TCGA-B5-A11E	UCEC	TCGA	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.1667
p.R1303H	DO41644	UCEC	ICGC	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.1667
p.K361N	TCGA-B5-A1MR	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation substituting flanking lysine	0.3056
p.K361N	DO41758	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation substituting flanking lysine	0.3056
p.S205L	TCGA-BB-A5HU	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.S205L	DO218977	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1667
p.A366T	TCGA-BH-A0HF	BRCA	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.A366T	DO1749	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation altering degron motif	0.7139
p.A984V	TCGA-BR-8078	STAD	TCGA	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0556
p.A984V	DO38288	STAD	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.0556
p.S1335R	TCGA-CA-6717	COAD	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0833
p.S1335R	DO8264	COAD	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.0833
p.R1303C	TCGA-CM-5863	COAD	TCGA	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.1667
p.R1303C	DO9026	COAD	ICGC	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.1667
p.R749K	TCGA-D3-A5GU	SKCM	TCGA	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1667
p.R749K	DO47584	SKCM	ICGC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1667
p.G1345E	TCGA-D9-A148	SKCM	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation altering degron motif	0.6087
p.G1345E	DO37971	SKCM	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation altering degron motif	0.6087
p.G1345R	TCGA-D9-A148	SKCM	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation altering degron motif	0.6457
p.G1345R	DO37971	SKCM	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation altering degron motif	0.6457
p.H209Y	TCGA-DK-A1AB	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.H209Y	DO461	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.L701V	TCGA-DR-A0ZM	CESC	TCGA	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.0556
p.L701V	DO6254	CESC	ICGC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.0556
p.S584A	TCGA-DX-AB2W	SARC	TCGA	VESST	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7588
p.S584A	DO220095	SARC	ICGC	VESST	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7588
p.L374F	TCGA-EE-A29E	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.2222
p.L374F	DO37831	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.2222
p.P360T	TCGA-EE-A2GH	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1667
p.P360T	DO37643	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1667
p.S714F	TCGA-EE-A2GI	SKCM	TCGA	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation altering degron motif	0.7982
p.S714F	DO37410	SKCM	ICGC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation altering degron motif	0.7982
p.F1362C	TCGA-EE-A2M5	SKCM	TCGA	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.1111
p.F1362C	DO222423	MELA	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.1111
p.F1362C	DO37425	SKCM	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.1111
p.P360S	TCGA-EE-A2MU	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1667
p.P360S	DO37436	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1667
p.R364S	TCGA-EO-A22R	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.2778
p.R364S	DO42713	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.2778
p.S213N	TCGA-EY-A215	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7069
p.S213N	DO42665	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7069
p.S982Y	TCGA-FS-A1ZZ	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1111
p.S982Y	DO37412	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1111
p.S363C	TCGA-G2-A3IE	BLCA	TCGA	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.25
p.S363C	DO767	BLCA	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.25
p.D1289H	TCGA-KL-8341	KICH	TCGA	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.25
p.D1289H	DO220349	KICH	ICGC	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.25
p.S722Y	TCGA-RC-A7SK	LIHC	TCGA	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1389
p.S722Y	DO52314	LIHC	ICGC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1389
p.S594L	DO218173	BRCA	ICGC	VESST	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.0833
p.A204S	DO222913	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1389
p.S213R	DO6695	CLLE	ICGC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7427
p.V980L	DO229010	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.V980L	DO229013	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.V980L	DO229016	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.V980L	DO229003	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.V980L	DO229005	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.V980L	DO50334	ESAD	ICGC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.1667
p.P1294Q	DO229029	LICA	ICGC	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation altering degron motif	0.7035
p.T356K	DO229038	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation blocking phosphorylation signal	0.5
p.P1339Q	DO229008	LICA	ICGC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.1944
p.Q735K	DO229008	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.2222
p.R62H	DO50970	LICA	ICGC	LAPLAGAGLELQL	DEG_ODPH_VHL_1	44:56	Mutation rewiring degron network	0.1667
p.R62H	DO50970	LICA	ICGC	PPPTPPRE	DEG_SCF_FBW7_2	64:71	Mutation rewiring degron network	0.2778
p.P745H	DO222354	LICA	ICGC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.2778
p.P1302S	DO222395	MELA	ICGC	MSPYAE	LIG_APCC_ABBA_1	1292:1297	Mutation rewiring degron network	0.1944
p.S722F	DO222875	MELA	ICGC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1389
p.D218N	DO51520	PACA	ICGC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.G201C	DO229227	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.G1355V	SIDM00683	Prostate Carcinoma	GDSC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.G1355V	ACH-000977	lymph node	CCLE	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.G1355V	LNCaP-Clone-FGC	prostate	COSMIC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.3056
p.S375L	SIDM00545	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1944
p.S375L	ACH-000987	Skin Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1944
p.S375L	Mewo	skin	COSMIC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.1944
p.L373F	SIDM00545	Melanoma	GDSC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.25
p.L373F	ACH-000987	Skin Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.25
p.L373F	Mewo	skin	COSMIC	ATTSS	DEG_SPOP_SBC_1	366:370	Mutation rewiring degron network	0.25
p.P730S	SIDM00718	Non-Small Cell Lung Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.0833
p.P730S	ACH-000860	Lung Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.0833
p.P730S	NCI-H358	lung	COSMIC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.0833
p.E219D	SIDM00193	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.E219D	ACH-000991	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.E219D	SNU-81	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.S704Y	SIDM00520	Mesothelioma	GDSC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1389
p.S704Y	ACH-002134	Lung Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1389
p.S704Y	H2818	pleura	COSMIC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation rewiring degron network	0.1389
p.P977S	SIDM01113	Other Sarcomas	GDSC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.25
p.P977S	ACH-000939	Sarcoma	CCLE	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.25
p.P977S	SK-UT-1	soft tissue	COSMIC	VQSST	DEG_SPOP_SBC_1	970:974	Mutation rewiring degron network	0.25
p.E825V	SIDM00391	Plasma Cell Myeloma	GDSC	PATST	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2222
p.E825V	ACH-000363	Myeloma	CCLE	PATST	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2222
p.E825V	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	PATST	DEG_SPOP_SBC_1	829:833	Mutation rewiring degron network	0.2222
p.S732F	SIDM00240	Cervical Carcinoma	GDSC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1389
p.S732F	ACH-002180	Cervical Cancer	CCLE	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1389
p.S732F	OMC-1	cervix	COSMIC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation rewiring degron network	0.1389
p.S713F	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation altering degron motif	0.7982
p.S713F	ACH-001362	Lung Cancer	CCLE	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation altering degron motif	0.7982
p.S713F	NCI-H1770	lung	COSMIC	PWSSS	DEG_SPOP_SBC_1	711:715	Mutation altering degron motif	0.7982
p.G1345V	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation altering degron motif	0.6421
p.G1345V	ACH-000053	Lymphoma	CCLE	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation altering degron motif	0.6421
p.G1345V	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation altering degron motif	0.6421
p.P1339T	SIDM00192	Colorectal Carcinoma	GDSC	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.1944
p.P1339T	ACH-000286	Colon/Colorectal Cancer	CCLE	NGLYPAYTGLP	CBL_PTK	1344:1354	Mutation rewiring degron network	0.1944
p.S743F	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PQSSS	DEG_SPOP_SBC_1	739:743	Mutation altering degron motif	0.7982
p.A90P	ACH-000997	Colon/Colorectal Cancer	CCLE	PATPGPS	DEG_SCF_FBW7_1	75:81	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HEG1

UniProt ID: Q9ULI3

Entrez ID: 57493

Protein name: Protein HEG homolog 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HEG1 in