DegronMD

Uniprot ID: Q9ULI3

Source protein: Protein HEG homolog 1

Source gene: HEG1

Class: CBL_PTK

Location: 1344:1354

E3 ligase: CBL

DEGRON score: 0.9982

ASA_SCORE: 63.7727

COIL: 0.9006

CONS_SCORE: 0.8758

DSS_SCORE: 0.369

HELIX: 0.054

FCONS_SCORE: 1.0225

RIG_SCORE: 0.7267

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1364R	TCGA-61-2018	OV	TCGA	NGLYPAYTGLP	CBL_PTK	0.0556
p.G1364R	TCGA-96-8170	LUSC	TCGA	NGLYPAYTGLP	CBL_PTK	0.0556
p.G1364R	TCGA-VQ-A8PT	STAD	TCGA	NGLYPAYTGLP	CBL_PTK	0.0556
p.G1364R	DO27691	LUSC	ICGC	NGLYPAYTGLP	CBL_PTK	0.0556
p.G1364R	DO29218	OV	ICGC	NGLYPAYTGLP	CBL_PTK	0.0556
p.G1364R	DO51776	STAD	ICGC	NGLYPAYTGLP	CBL_PTK	0.0556
p.G1364R	SIDM01617	Endometrial Carcinoma	GDSC	NGLYPAYTGLP	CBL_PTK	0.0556
p.G1364R	ACH-000994	Endometrial/Uterine Cancer	CCLE	NGLYPAYTGLP	CBL_PTK	0.0556
p.R1343Q	TCGA-AG-3892	READ	TCGA	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	TCGA-AP-A056	UCEC	TCGA	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	TCGA-EO-A3AY	UCEC	TCGA	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	TCGA-EO-A3B0	UCEC	TCGA	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	DO36394	READ	ICGC	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	DO219773	UCEC	ICGC	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	DO43202	UCEC	ICGC	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	DO43971	UCEC	ICGC	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	SIDM00545	Melanoma	GDSC	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	ACH-000987	Skin Cancer	CCLE	NGLYPAYTGLP	CBL_PTK	0.3056
p.R1343Q	Mewo	skin	COSMIC	NGLYPAYTGLP	CBL_PTK	0.3056
p.S1335R	TCGA-CA-6717	COAD	TCGA	NGLYPAYTGLP	CBL_PTK	0.0833
p.S1335R	DO8264	COAD	ICGC	NGLYPAYTGLP	CBL_PTK	0.0833
p.G1345E	TCGA-D9-A148	SKCM	TCGA	NGLYPAYTGLP	CBL_PTK	0.6087
p.G1345E	DO37971	SKCM	ICGC	NGLYPAYTGLP	CBL_PTK	0.6087
p.G1345R	TCGA-D9-A148	SKCM	TCGA	NGLYPAYTGLP	CBL_PTK	0.6457
p.G1345R	DO37971	SKCM	ICGC	NGLYPAYTGLP	CBL_PTK	0.6457
p.F1362C	TCGA-EE-A2M5	SKCM	TCGA	NGLYPAYTGLP	CBL_PTK	0.1111
p.F1362C	DO222423	MELA	ICGC	NGLYPAYTGLP	CBL_PTK	0.1111
p.F1362C	DO37425	SKCM	ICGC	NGLYPAYTGLP	CBL_PTK	0.1111
p.P1339Q	DO229008	LICA	ICGC	NGLYPAYTGLP	CBL_PTK	0.1944
p.G1355V	SIDM00683	Prostate Carcinoma	GDSC	NGLYPAYTGLP	CBL_PTK	0.3056
p.G1355V	ACH-000977	lymph_node	CCLE	NGLYPAYTGLP	CBL_PTK	0.3056
p.G1355V	LNCaP-Clone-FGC	prostate	COSMIC	NGLYPAYTGLP	CBL_PTK	0.3056
p.G1345V	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	NGLYPAYTGLP	CBL_PTK	0.6421
p.G1345V	ACH-000053	Lymphoma	CCLE	NGLYPAYTGLP	CBL_PTK	0.6421
p.G1345V	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	NGLYPAYTGLP	CBL_PTK	0.6421
p.P1339T	SIDM00192	Colorectal Carcinoma	GDSC	NGLYPAYTGLP	CBL_PTK	0.1944
p.P1339T	ACH-000286	Colon/Colorectal Cancer	CCLE	NGLYPAYTGLP	CBL_PTK	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NGLYPAYTGLP

Degron related mutations and impact score

Drug responses associated with HEG1 mutations

All proteins holding degron of NGLYPAYTGLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULI3	Protein HEG homolog 1	CBL_PTK	1344:1354	NGLYPAYTGLP	CBL	0.9982	More...