DegronMD

Uniprot ID: Q9ULI3

Source protein: Protein HEG homolog 1

Source gene: HEG1

Class: LIG_APCC_ABBA_1

Location: 1292:1297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8399

ASA_SCORE: 70.9833

COIL: 0.8978

CONS_SCORE: 0.8375

DSS_SCORE: 0.4057

HELIX: 0.0553

FCONS_SCORE: 1.0078

RIG_SCORE: 0.7309

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1289Y	TCGA-60-2723	LUSC	TCGA	MSPYAE	LIG_APCC_ABBA_1	0.25
p.D1289Y	DO27152	LUSC	ICGC	MSPYAE	LIG_APCC_ABBA_1	0.25
p.R1303H	TCGA-B5-A11E	UCEC	TCGA	MSPYAE	LIG_APCC_ABBA_1	0.1667
p.R1303H	DO41644	UCEC	ICGC	MSPYAE	LIG_APCC_ABBA_1	0.1667
p.R1303C	TCGA-CM-5863	COAD	TCGA	MSPYAE	LIG_APCC_ABBA_1	0.1667
p.R1303C	DO9026	COAD	ICGC	MSPYAE	LIG_APCC_ABBA_1	0.1667
p.D1289H	TCGA-KL-8341	KICH	TCGA	MSPYAE	LIG_APCC_ABBA_1	0.25
p.D1289H	DO220349	KICH	ICGC	MSPYAE	LIG_APCC_ABBA_1	0.25
p.P1294Q	DO229029	LICA	ICGC	MSPYAE	LIG_APCC_ABBA_1	0.7035
p.P1302S	DO222395	MELA	ICGC	MSPYAE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULI3	Protein HEG homolog 1	LIG_APCC_ABBA_1	1292:1297	MSPYAE	APC,CDC20,FZR1	0.8399	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons