DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LAPLAGAGLELQL
Uniprot ID:
Q9ULI3
Source protein:
Protein HEG homolog 1
Source gene:
HEG1
Class:
DEG_ODPH_VHL_1
Location:
44:56
E3 ligase:
VHL
DEGRON score:
0.9902
ASA_SCORE:
78.4462
COIL:
0.7692
CONS_SCORE:
0.2826
DSS_SCORE:
0.6448
HELIX:
0.1726
FCONS_SCORE:
0.9954
RIG_SCORE:
0.6553
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R62H
DO50970
LICA
ICGC
LAPLAGAGLELQL
DEG_ODPH_VHL_1
0.1667
Drug responses associated with HEG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LAPLAGAGLELQL
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9ULI3
Protein HEG homolog 1
DEG_ODPH_VHL_1
44:56
LAPLAGAGLELQL
VHL
0.9902
More...