DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PPPTPPRE
Uniprot ID:
Q9ULI3
Source protein:
Protein HEG homolog 1
Source gene:
HEG1
Class:
DEG_SCF_FBW7_2
Location:
64:71
E3 ligase:
FBXW7
DEGRON score:
0.8321
ASA_SCORE:
109.1125
COIL:
0.9669
CONS_SCORE:
0.2683
DSS_SCORE:
0.9174
HELIX:
0.0178
FCONS_SCORE:
1.0761
RIG_SCORE:
0.5135
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R62H
DO50970
LICA
ICGC
PPPTPPRE
DEG_SCF_FBW7_2
0.2778
Drug responses associated with HEG1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PPPTPPRE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9ULI3
Protein HEG homolog 1
DEG_SCF_FBW7_2
64:71
PPPTPPRE
FBXW7
0.8321
More...