DegronMD

Uniprot ID: Q9ULI3

Source protein: Protein HEG homolog 1

Source gene: HEG1

Class: DEG_SPOP_SBC_1

Location: 970:974

E3 ligase: SPOP

DEGRON score: 0.893

ASA_SCORE: 84.24

COIL: 0.8396

CONS_SCORE: 0.5549

DSS_SCORE: 0.45

HELIX: 0.0288

FCONS_SCORE: 1.0665

RIG_SCORE: 0.691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A984T	TCGA-A5-A0G1	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.0556
p.A984T	DO42472	UCEC	ICGC	VQSST	DEG_SPOP_SBC_1	0.0556
p.A984V	TCGA-BR-8078	STAD	TCGA	VQSST	DEG_SPOP_SBC_1	0.0556
p.A984V	DO38288	STAD	ICGC	VQSST	DEG_SPOP_SBC_1	0.0556
p.S982Y	TCGA-FS-A1ZZ	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	0.1111
p.S982Y	DO37412	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	0.1111
p.V980L	DO229010	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.1667
p.V980L	DO229013	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.1667
p.V980L	DO229016	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.1667
p.V980L	DO229003	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.1667
p.V980L	DO229005	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.1667
p.V980L	DO50334	ESAD	ICGC	VQSST	DEG_SPOP_SBC_1	0.1667
p.P977S	SIDM01113	Other Sarcomas	GDSC	VQSST	DEG_SPOP_SBC_1	0.25
p.P977S	ACH-000939	Sarcoma	CCLE	VQSST	DEG_SPOP_SBC_1	0.25
p.P977S	SK-UT-1	soft_tissue	COSMIC	VQSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	DEG_SPOP_SBC_1	727:731	VQSST	SPOP	0.9853	More...
O95125	Zinc finger protein 202	DEG_SPOP_SBC_1	166:170	VQSST	SPOP	0.8483	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	374:378	VQSST	SPOP	0.7965	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	970:974	VQSST	SPOP	0.893	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	578:582	VQSST	SPOP	0.7764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons