DegronMD

Uniprot ID: Q9C0C7

Source protein: Activating molecule in BECN1-regulated autophagy protein 1

Source gene: AMBRA1

Class: DEG_SPOP_SBC_1

Location: 374:378

E3 ligase: SPOP

DEGRON score: 0.7965

ASA_SCORE: 61.66

COIL: 0.5148

CONS_SCORE: 0.4338

DSS_SCORE: 0.5646

HELIX: 0.107

FCONS_SCORE: 1.0079

RIG_SCORE: 0.6758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R380S	TCGA-A5-A0G2	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.2778
p.R380S	DO41235	UCEC	ICGC	VQSST	DEG_SPOP_SBC_1	0.2778
p.T374A	TCGA-AJ-A8CV	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.7139
p.T374A	DO219766	UCEC	ICGC	VQSST	DEG_SPOP_SBC_1	0.7139
p.R380M	TCGA-DI-A1BU	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.2778
p.R380M	DO42023	UCEC	ICGC	VQSST	DEG_SPOP_SBC_1	0.2778
p.G386E	TCGA-DU-6392	LGG	TCGA	VQSST	DEG_SPOP_SBC_1	0.1111
p.G386E	DO22237	LGG	ICGC	VQSST	DEG_SPOP_SBC_1	0.1111
p.Y373C	DO227987	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.3056
p.A388E	DO229035	LICA	ICGC	VQSST	DEG_SPOP_SBC_1	0.0556
p.R367Q	SIDM01617	Endometrial Carcinoma	GDSC	VQSST	DEG_SPOP_SBC_1	0.1389
p.S377N	SIDM01729	Endometrial Carcinoma	GDSC	VQSST	DEG_SPOP_SBC_1	0.7069
p.G379E	ACH-000564	Myeloma	CCLE	VQSST	DEG_SPOP_SBC_1	0.3056
p.A384S	ACH-000786	Lymphoma	CCLE	VQSST	DEG_SPOP_SBC_1	0.1667
p.A384S	ACH-000992	Head and Neck Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	0.1667
p.A384S	S-117	soft_tissue	COSMIC	VQSST	DEG_SPOP_SBC_1	0.1667
p.A384S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	VQSST	DEG_SPOP_SBC_1	0.1667
p.A384S	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	VQSST	DEG_SPOP_SBC_1	0.1667
p.P383L	ACH-001399	Colon/Colorectal Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	0.1944
p.P383L	SW626	ovary	COSMIC	VQSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	DEG_SPOP_SBC_1	727:731	VQSST	SPOP	0.9853	More...
O95125	Zinc finger protein 202	DEG_SPOP_SBC_1	166:170	VQSST	SPOP	0.8483	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	374:378	VQSST	SPOP	0.7965	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	970:974	VQSST	SPOP	0.893	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	578:582	VQSST	SPOP	0.7764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons