DegronMD - Q9Y2H0(DLGAP4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P561L	TCGA-86-8073	LUAD	TCGA	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.P561L	TCGA-AG-A02N	READ	TCGA	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.P561L	SIDM02035	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.P561L	SIDM00936	Bladder Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.P561L	ACH-000142	Bladder Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.P561L	CAL-29	urinary tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.1944
p.R73C	TCGA-97-A4M7	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.25
p.R73C	DO45386	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.25
p.H75Y	TCGA-A2-A1FV	BRCA	TCGA	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1944
p.H75Y	DO5235	BRCA	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1944
p.L590M	TCGA-A6-6781	COAD	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1111
p.D976N	TCGA-A8-A09N	BRCA	TCGA	DSIEIYVPEA	DEG_COP1_1	979:988	Mutation rewiring degron network	0.25
p.P572Q	TCGA-B5-A1MX	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2778
p.P572Q	TCGA-B5-A1MX	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.D587A	TCGA-B5-A3FA	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1944
p.Q403L	TCGA-B7-A5TI	STAD	TCGA	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.0833
p.Q403L	DO222328	STAD	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.0833
p.T588A	TCGA-BS-A0VI	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.1667
p.T568A	TCGA-CG-5721	STAD	TCGA	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation altering degron motif	0.7139
p.D976H	TCGA-CV-6961	HNSC	TCGA	DSIEIYVPEA	DEG_COP1_1	979:988	Mutation rewiring degron network	0.25
p.P72L	TCGA-D3-A3CB	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P72L	DO47386	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.N411S	TCGA-EE-A29D	SKCM	TCGA	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.3056
p.N411S	DO38123	SKCM	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.3056
p.I574V	TCGA-F4-6703	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2222
p.I574V	TCGA-F4-6703	COAD	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.I574V	TCGA-WS-AB45	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	566:570	Mutation rewiring degron network	0.2222
p.I574V	TCGA-WS-AB45	COAD	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.2222
p.E583Q	TCGA-G3-A3CK	LIHC	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation rewiring degron network	0.3056
p.S581I	TCGA-L9-A8F4	LUAD	TCGA	VQSST	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.7341
p.D71H	DO224980	BRCA	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.3056
p.R414C	DO51638	CESC	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.719
p.R414C	DO223541	CLLE	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.719
p.R418H	DO49952	CESC	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.7133
p.D74A	DO9010	COAD	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.P79Q	DO222505	ESCA	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.0833
p.D74E	DO222285	GACA	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.A409T	DO233616	GACA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.25
p.R418L	DO228976	LICA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.7316
p.A424S	DO229029	LICA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.2222
p.S62I	DO229041	LICA	ICGC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.N411K	DO35116	PACA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.3056
p.R426L	DO37421	SKCM	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1667
p.D404N	DO48020	STAD	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1111
p.G407V	DO229148	THCA	ICGC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1944
p.S581G	SIDM00697	Small Cell Lung Carcinoma	GDSC	VQSST	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.6993
p.S581G	ACH-000830	Lung Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.6993
p.S581G	NCI-H1436	lung	COSMIC	VQSST	DEG_SPOP_SBC_1	578:582	Mutation altering degron motif	0.6993
p.P72H	SIDM00120	Prostate Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P72H	ACH-000979	Prostate Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.P72H	DU-145	prostate	COSMIC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2778
p.Y76C	SIDM00748	Non-Small Cell Lung Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.Y76C	ACH-000015	Lung Cancer	CCLE	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.Y76C	NCI-H1581	lung	COSMIC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1667
p.R418C	SIDM00801	Melanoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.719
p.R418C	A101D	skin	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.719
p.A985T	SIDM00516	Melanoma	GDSC	DSIEIYVPEA	DEG_COP1_1	979:988	Mutation altering degron motif	0.7139
p.A985T	ACH-002166	Skin Cancer	CCLE	DSIEIYVPEA	DEG_COP1_1	979:988	Mutation altering degron motif	0.7139
p.A985T	MZ7-mel	skin	COSMIC	DSIEIYVPEA	DEG_COP1_1	979:988	Mutation altering degron motif	0.7139
p.L425M	SIDM00826	Colorectal Carcinoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1944
p.L425M	ACH-001039	Colon/Colorectal Cancer	CCLE	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1944
p.L425M	COLO-205	large intestine	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1944
p.D417G	SIDM00976	Melanoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6087
p.D417G	ACH-002205	Skin Cancer	CCLE	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6087
p.D417G	WM1552C	skin	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.6087
p.L416M	SIDM01397	Melanoma	GDSC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.711
p.L416M	ACH-000765	Skin Cancer	CCLE	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.711
p.A406V	LS-411N	large intestine	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation rewiring degron network	0.1667
p.S74I	IGROV-1	ovary	COSMIC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.2222
p.A988T	MZ7-mel	skin	COSMIC	DSIEIYVPEA	DEG_COP1_1	979:988	Mutation altering degron motif	0.7139
p.S69L	KMS-11	haematopoietic and lymphoid tissue	COSMIC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation altering degron motif	0.7667
p.K412T	HEC-1	endometrium	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.7306
p.R414H	CCK-81	large intestine	COSMIC	PRRSLDRLD	DEG_APCC_DBOX_1	412:420	Mutation altering degron motif	0.7133
p.S61I	IGROV-1	ovary	COSMIC	PPSST	DEG_SPOP_SBC_1	66:70	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLGAP4

UniProt ID: Q9Y2H0

Entrez ID: 22839

Protein name: Disks large-associated protein 4 (DAP-4) (PSD-95/SAP90-binding protein 4) (SAP90/PSD-95-associated protein 4) (SAPAP-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLGAP4 in