DegronMD

Uniprot ID: Q9Y2H0

Source protein: Disks large-associated protein 4

Source gene: DLGAP4

Class: DEG_COP1_1

Location: 979:988

E3 ligase: COP1

DEGRON score: 0.97

ASA_SCORE: 64.53

COIL: 0.434

CONS_SCORE: 0.6418

DSS_SCORE: 0.465

HELIX: 0.0836

FCONS_SCORE: 1.2305

RIG_SCORE: 0.7944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D976N	TCGA-A8-A09N	BRCA	TCGA	DSIEIYVPEA	DEG_COP1_1	0.25
p.D976H	TCGA-CV-6961	HNSC	TCGA	DSIEIYVPEA	DEG_COP1_1	0.25
p.A985T	SIDM00516	Melanoma	GDSC	DSIEIYVPEA	DEG_COP1_1	0.7139
p.A985T	ACH-002166	Skin Cancer	CCLE	DSIEIYVPEA	DEG_COP1_1	0.7139
p.A985T	MZ7-mel	skin	COSMIC	DSIEIYVPEA	DEG_COP1_1	0.7139
p.A988T	MZ7-mel	skin	COSMIC	DSIEIYVPEA	DEG_COP1_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2H0	Disks large-associated protein 4	DEG_COP1_1	979:988	DSIEIYVPEA	COP1	0.97	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons