DegronMD

Uniprot ID: Q9Y2H0

Source protein: Disks large-associated protein 4

Source gene: DLGAP4

Class: DEG_SPOP_SBC_1

Location: 578:582

E3 ligase: SPOP

DEGRON score: 0.7764

ASA_SCORE: 86.02

COIL: 0.805

CONS_SCORE: 0.5065

DSS_SCORE: 0.495

HELIX: 0.0562

FCONS_SCORE: 1.0015

RIG_SCORE: 0.7035

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L590M	TCGA-A6-6781	COAD	TCGA	VQSST	DEG_SPOP_SBC_1	0.1111
p.P572Q	TCGA-B5-A1MX	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.1667
p.D587A	TCGA-B5-A3FA	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.1944
p.T588A	TCGA-BS-A0VI	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.1667
p.I574V	TCGA-F4-6703	COAD	TCGA	VQSST	DEG_SPOP_SBC_1	0.2222
p.I574V	TCGA-WS-AB45	COAD	TCGA	VQSST	DEG_SPOP_SBC_1	0.2222
p.E583Q	TCGA-G3-A3CK	LIHC	TCGA	VQSST	DEG_SPOP_SBC_1	0.3056
p.S581I	TCGA-L9-A8F4	LUAD	TCGA	VQSST	DEG_SPOP_SBC_1	0.7341
p.S581G	SIDM00697	Small Cell Lung Carcinoma	GDSC	VQSST	DEG_SPOP_SBC_1	0.6993
p.S581G	ACH-000830	Lung Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	0.6993
p.S581G	NCI-H1436	lung	COSMIC	VQSST	DEG_SPOP_SBC_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	DEG_SPOP_SBC_1	727:731	VQSST	SPOP	0.9853	More...
O95125	Zinc finger protein 202	DEG_SPOP_SBC_1	166:170	VQSST	SPOP	0.8483	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	374:378	VQSST	SPOP	0.7965	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	970:974	VQSST	SPOP	0.893	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	578:582	VQSST	SPOP	0.7764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons