DegronMD

Uniprot ID: A6ND36

Source protein: Protein FAM83G

Source gene: FAM83G

Class: DEG_SPOP_SBC_1

Location: 727:731

E3 ligase: SPOP

DEGRON score: 0.9853

ASA_SCORE: 78.14

COIL: 0.8356

CONS_SCORE: 0.3068

DSS_SCORE: 0.6761

HELIX: 0.065

FCONS_SCORE: 0.881

RIG_SCORE: 0.6258

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S729R	TCGA-UU-A93S	BRCA	TCGA	VQSST	DEG_SPOP_SBC_1	0.7427
p.S729R	DO219645	BRCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.7427
p.V727I	DO230311	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	0.7076
p.T731N	DO228978	LICA	ICGC	VQSST	DEG_SPOP_SBC_1	0.7055
p.N733T	ACH-002164	Pancreatic Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	0.2778
p.N733T	MZ1-PC	pancreas	COSMIC	VQSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	DEG_SPOP_SBC_1	727:731	VQSST	SPOP	0.9853	More...
O95125	Zinc finger protein 202	DEG_SPOP_SBC_1	166:170	VQSST	SPOP	0.8483	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	374:378	VQSST	SPOP	0.7965	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	970:974	VQSST	SPOP	0.893	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	578:582	VQSST	SPOP	0.7764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons