DegronMD

Uniprot ID: O95125

Source protein: Zinc finger protein 202

Source gene: ZNF202

Class: DEG_SPOP_SBC_1

Location: 166:170

E3 ligase: SPOP

DEGRON score: 0.8483

ASA_SCORE: 77.8

COIL: 0.783

CONS_SCORE: 0.5962

DSS_SCORE: 0.9262

HELIX: 0.1326

FCONS_SCORE: 1.0142

RIG_SCORE: 0.5551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E161K	TCGA-13-0795	OV	TCGA	VQSST	DEG_SPOP_SBC_1	0.1944
p.E161K	DO28321	OV	ICGC	VQSST	DEG_SPOP_SBC_1	0.1944
p.D164H	TCGA-55-8089	LUAD	TCGA	VQSST	DEG_SPOP_SBC_1	0.2778
p.D164H	DO23690	LUAD	ICGC	VQSST	DEG_SPOP_SBC_1	0.2778
p.S158A	TCGA-86-8358	LUAD	TCGA	VQSST	DEG_SPOP_SBC_1	0.1111
p.S158A	DO25471	LUAD	ICGC	VQSST	DEG_SPOP_SBC_1	0.1111
p.S169L	TCGA-AJ-A8CT	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	0.7667
p.S169L	TCGA-FW-A3R5	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	0.7667
p.S169L	DO37406	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	0.7667
p.S169L	DO52399	UCEC	ICGC	VQSST	DEG_SPOP_SBC_1	0.7667
p.S169L	ACH-002672	Pancreatic Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	0.7667
p.S168N	TCGA-EE-A3AA	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	0.7069
p.S168N	DO222632	MELA	ICGC	VQSST	DEG_SPOP_SBC_1	0.7069
p.S168N	DO37571	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	0.7069
p.P165H	TCGA-FS-A1ZJ	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	0.3056
p.P165H	DO37956	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	0.3056
p.L162M	DO228948	LICA	ICGC	VQSST	DEG_SPOP_SBC_1	0.2222
p.S174F	SIDM01768	Melanoma	GDSC	VQSST	DEG_SPOP_SBC_1	0.2222
p.S174F	ACH-000899	Skin Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	0.2222
p.D164Y	ACH-001719	Ovarian Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	DEG_SPOP_SBC_1	727:731	VQSST	SPOP	0.9853	More...
O95125	Zinc finger protein 202	DEG_SPOP_SBC_1	166:170	VQSST	SPOP	0.8483	More...
Q9C0C7	Activating molecule in BECN1-regulated autophagy protein 1	DEG_SPOP_SBC_1	374:378	VQSST	SPOP	0.7965	More...
Q9ULI3	Protein HEG homolog 1	DEG_SPOP_SBC_1	970:974	VQSST	SPOP	0.893	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	578:582	VQSST	SPOP	0.7764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons