DegronMD - O95125(ZNF202)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D360N	TCGA-05-4250	LUAD	TCGA	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation rewiring degron network	0.1944
p.D360N	DO24457	LUAD	ICGC	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation rewiring degron network	0.1944
p.E161K	TCGA-13-0795	OV	TCGA	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1944
p.E161K	DO28321	OV	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1944
p.D164H	TCGA-55-8089	LUAD	TCGA	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.D164H	DO23690	LUAD	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778
p.S158A	TCGA-86-8358	LUAD	TCGA	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.S158A	DO25471	LUAD	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.1111
p.P352T	TCGA-A5-A0G2	UCEC	TCGA	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation altering degron motif	0.7031
p.P352T	DO41235	UCEC	ICGC	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation altering degron motif	0.7031
p.E302D	TCGA-AA-3715	COAD	TCGA	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.2778
p.E302D	DO8018	COAD	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.2778
p.S169L	TCGA-AJ-A8CT	UCEC	TCGA	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7667
p.S169L	TCGA-FW-A3R5	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7667
p.S169L	DO37406	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7667
p.S169L	DO52399	UCEC	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7667
p.S169L	ACH-002672	Pancreatic Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7667
p.G363C	TCGA-B5-A0JR	UCEC	TCGA	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation rewiring degron network	0.1111
p.G363C	DO41791	UCEC	ICGC	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation rewiring degron network	0.1111
p.E294K	TCGA-DK-A2I6	BLCA	TCGA	EEEPWVPDI	DEG_COP1_1	292:300	Mutation altering degron motif	0.591
p.E294K	DO798	BLCA	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation altering degron motif	0.591
p.Q301K	TCGA-EE-A184	SKCM	TCGA	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.3056
p.Q301K	DO47442	SKCM	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.3056
p.W296L	TCGA-EE-A29L	SKCM	TCGA	EEEPWVPDI	DEG_COP1_1	292:300	Mutation altering degron motif	0.5904
p.W296L	DO37835	SKCM	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation altering degron motif	0.5904
p.S168N	TCGA-EE-A3AA	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7069
p.S168N	DO222632	MELA	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7069
p.S168N	DO37571	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation altering degron motif	0.7069
p.E359K	TCGA-FD-A3SS	BLCA	TCGA	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation rewiring degron network	0.2222
p.E359K	DO737	BLCA	ICGC	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation rewiring degron network	0.2222
p.P165H	TCGA-FS-A1ZJ	SKCM	TCGA	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.P165H	DO37956	SKCM	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.3056
p.D285V	TCGA-WX-AA47	LIHC	TCGA	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.1389
p.D285V	DO223919	LIHC	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.1389
p.H349Y	DO48413	BLCA	ICGC	IHQTPDWE	DEG_SCF_FBW7_2	348:355	Mutation altering degron motif	0.6118
p.Q307K	DO228726	LICA	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.1389
p.L162M	DO228948	LICA	ICGC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2222
p.Q289K	DO228971	LICA	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.25
p.I300F	DO46483	OV	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation altering degron motif	0.6304
p.P295H	DO229259	THCA	ICGC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation altering degron motif	0.6583
p.Q304R	SIDM00131	Glioma	GDSC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.2222
p.Q304R	ACH-000329	Brain Cancer	CCLE	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.2222
p.Q304R	CCF-STTG1	central nervous system	COSMIC	EEEPWVPDI	DEG_COP1_1	292:300	Mutation rewiring degron network	0.2222
p.S174F	SIDM01768	Melanoma	GDSC	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2222
p.S174F	ACH-000899	Skin Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2222
p.D164Y	ACH-001719	Ovarian Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	166:170	Mutation rewiring degron network	0.2778

Kaplan plot for ZNF202 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF202

UniProt ID: O95125

Entrez ID: 7753

Protein name: Zinc finger protein 202 (Zinc finger protein with KRAB and SCAN domains 10)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF202 in