DegronMD

Uniprot ID: O95125

Source protein: Zinc finger protein 202

Source gene: ZNF202

Class: DEG_COP1_1

Location: 292:300

E3 ligase: COP1

DEGRON score: 0.9459

ASA_SCORE: 105.4444

COIL: 0.8267

CONS_SCORE: 0.7205

DSS_SCORE: 0.6919

HELIX: 0.0473

FCONS_SCORE: 1.1201

RIG_SCORE: 0.7477

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E302D	TCGA-AA-3715	COAD	TCGA	EEEPWVPDI	DEG_COP1_1	0.2778
p.E302D	DO8018	COAD	ICGC	EEEPWVPDI	DEG_COP1_1	0.2778
p.E294K	TCGA-DK-A2I6	BLCA	TCGA	EEEPWVPDI	DEG_COP1_1	0.591
p.E294K	DO798	BLCA	ICGC	EEEPWVPDI	DEG_COP1_1	0.591
p.Q301K	TCGA-EE-A184	SKCM	TCGA	EEEPWVPDI	DEG_COP1_1	0.3056
p.Q301K	DO47442	SKCM	ICGC	EEEPWVPDI	DEG_COP1_1	0.3056
p.W296L	TCGA-EE-A29L	SKCM	TCGA	EEEPWVPDI	DEG_COP1_1	0.5904
p.W296L	DO37835	SKCM	ICGC	EEEPWVPDI	DEG_COP1_1	0.5904
p.D285V	TCGA-WX-AA47	LIHC	TCGA	EEEPWVPDI	DEG_COP1_1	0.1389
p.D285V	DO223919	LIHC	ICGC	EEEPWVPDI	DEG_COP1_1	0.1389
p.Q307K	DO228726	LICA	ICGC	EEEPWVPDI	DEG_COP1_1	0.1389
p.Q289K	DO228971	LICA	ICGC	EEEPWVPDI	DEG_COP1_1	0.25
p.I300F	DO46483	OV	ICGC	EEEPWVPDI	DEG_COP1_1	0.6304
p.P295H	DO229259	THCA	ICGC	EEEPWVPDI	DEG_COP1_1	0.6583
p.Q304R	SIDM00131	Glioma	GDSC	EEEPWVPDI	DEG_COP1_1	0.2222
p.Q304R	ACH-000329	Brain Cancer	CCLE	EEEPWVPDI	DEG_COP1_1	0.2222
p.Q304R	CCF-STTG1	central_nervous_system	COSMIC	EEEPWVPDI	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95125	Zinc finger protein 202	DEG_COP1_1	292:300	EEEPWVPDI	COP1	0.9459	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons