DegronMD - A6ND36(FAM83G)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G713R	TCGA-92-8063	LUSC	TCGA	PPRY	ITCH	717:720	Mutation rewiring degron network	0.2222
p.G713R	DO26941	LUSC	ICGC	PPRY	ITCH	717:720	Mutation rewiring degron network	0.2222
p.S60W	TCGA-E7-A7XN	BLCA	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.6763
p.S60W	DO51878	BLCA	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation altering degron motif	0.6763
p.R52L	TCGA-EE-A3AA	SKCM	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.R52L	DO37571	SKCM	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.R52W	TCGA-EO-A22U	UCEC	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.R52W	DO43755	UCEC	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.R52W	ACH-001647	Leukemia	CCLE	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.S729R	TCGA-UU-A93S	BRCA	TCGA	VQSST	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.7427
p.S729R	DO219645	BRCA	ICGC	VQSST	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.7427
p.E53D	TCGA-UY-A8OB	BLCA	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.E53D	DO219037	BLCA	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.2778
p.V727I	DO230311	COCA	ICGC	VQSST	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.7076
p.T731N	DO228978	LICA	ICGC	VQSST	DEG_SPOP_SBC_1	727:731	Mutation altering degron motif	0.7055
p.R66S	DO228985	LICA	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	55:63	Mutation rewiring degron network	0.25
p.G713D	DO222644	MELA	ICGC	PPRY	ITCH	717:720	Mutation rewiring degron network	0.2222
p.G713S	DO222710	MELA	ICGC	PPRY	ITCH	717:720	Mutation rewiring degron network	0.2222
p.P718A	ACH-001302	Neuroblastoma	CCLE	PPRY	ITCH	717:720	Mutation altering degron motif	0.7503
p.N733T	ACH-002164	Pancreatic Cancer	CCLE	VQSST	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2778
p.N733T	MZ1-PC	pancreas	COSMIC	VQSST	DEG_SPOP_SBC_1	727:731	Mutation rewiring degron network	0.2778

Kaplan plot for FAM83G in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM83G

UniProt ID: A6ND36

Entrez ID: 644815

Protein name: Protein FAM83G (Protein associated with SMAD1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM83G in