DegronMD

Uniprot ID: A6ND36

Source protein: Protein FAM83G

Source gene: FAM83G

Class: DEG_APCC_DBOX_1

Location: 55:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6106

ASA_SCORE: 63.9444

COIL: 0.605

CONS_SCORE: 0.908

DSS_SCORE: 0.0896

HELIX: 0.3709

FCONS_SCORE: 1.2519

RIG_SCORE: 0.8856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S60W	TCGA-E7-A7XN	BLCA	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	0.6763
p.S60W	DO51878	BLCA	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	0.6763
p.R52L	TCGA-EE-A3AA	SKCM	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	0.25
p.R52L	DO37571	SKCM	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	0.25
p.R52W	TCGA-EO-A22U	UCEC	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	0.25
p.R52W	DO43755	UCEC	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	0.25
p.R52W	ACH-001647	Leukemia	CCLE	IRDFLSELE	DEG_APCC_DBOX_1	0.25
p.E53D	TCGA-UY-A8OB	BLCA	TCGA	IRDFLSELE	DEG_APCC_DBOX_1	0.2778
p.E53D	DO219037	BLCA	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	0.2778
p.R66S	DO228985	LICA	ICGC	IRDFLSELE	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6ND36	Protein FAM83G	DEG_APCC_DBOX_1	55:63	IRDFLSELE	APC,CDC20,FZR1	0.6106	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons