DegronMD

Uniprot ID: Q9Y2H0

Source protein: Disks large-associated protein 4

Source gene: DLGAP4

Class: DEG_SPOP_SBC_1

Location: 566:570

E3 ligase: SPOP

DEGRON score: 0.9951

ASA_SCORE: 106.18

COIL: 0.9484

CONS_SCORE: 0.5909

DSS_SCORE: 0.5726

HELIX: 0.0232

FCONS_SCORE: 1.1943

RIG_SCORE: 0.6677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P561L	TCGA-86-8073	LUAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1944
p.P561L	TCGA-AG-A02N	READ	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1944
p.P561L	SIDM02035	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.P561L	SIDM00936	Bladder Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.P561L	ACH-000142	Bladder Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.1944
p.P561L	CAL-29	urinary_tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.P572Q	TCGA-B5-A1MX	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	0.2778
p.T568A	TCGA-CG-5721	STAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.7139
p.I574V	TCGA-F4-6703	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.2222
p.I574V	TCGA-WS-AB45	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons