DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 4014:4018

E3 ligase: SPOP

DEGRON score: 0.8354

ASA_SCORE: 97.28

COIL: 0.8748

CONS_SCORE: 0.7441

DSS_SCORE: 0.5983

HELIX: 0.0214

FCONS_SCORE: 1.1125

RIG_SCORE: 0.6786

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G4020D	TCGA-CV-7568	HNSC	TCGA	PRTTS	DEG_SPOP_SBC_1	0.2778
p.G4020D	DO14160	HNSC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.2778
p.R4019I	TCGA-FI-A2D5	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	0.3056
p.R4019I	DO41331	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.3056
p.T4027M	DO229022	LICA	ICGC	PRTTS	DEG_SPOP_SBC_1	0.0833
p.T4027A	SIDM00498	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.0833
p.T4027A	ACH-000970	Colon/Colorectal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.0833
p.T4027A	SNU-C5	large_intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons