DegronMD

Uniprot ID: Q14678

Source protein: KN motif and ankyrin repeat domain-containing protein 1

Source gene: KANK1

Class: DEG_SPOP_SBC_1

Location: 76:80

E3 ligase: SPOP

DEGRON score: 0.5682

ASA_SCORE: 82.66

COIL: 0.8764

CONS_SCORE: 0.3042

DSS_SCORE: 0.6601

HELIX: 0.0528

FCONS_SCORE: 0.861

RIG_SCORE: 0.6372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R67W	TCGA-32-2616	GBM	TCGA	PRTTS	DEG_SPOP_SBC_1	0.0833
p.R67W	DO13462	GBM	ICGC	PRTTS	DEG_SPOP_SBC_1	0.0833
p.W86C	TCGA-B5-A3FC	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1667
p.W86C	DO41871	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1667
p.V71L	TCGA-CA-6719	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	0.1944
p.V71L	DO9234	COAD	ICGC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.I85M	SIDM00480	Ovarian Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.S80F	SIDM01175	Other Sarcomas	GDSC	PRTTS	DEG_SPOP_SBC_1	0.7982
p.S80F	ACH-002309	Sarcoma	CCLE	PRTTS	DEG_SPOP_SBC_1	0.7982
p.S80F	SW684	soft_tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.7982
p.P69L	SIDM01099	Neuroblastoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1389
p.P69L	SIDM00863	Burkitt's Lymphoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1389
p.V71M	SIDM00839	Colorectal Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	0.1944
p.V71M	ACH-000950	Colon/Colorectal Cancer	CCLE	PRTTS	DEG_SPOP_SBC_1	0.1944
p.V71M	LoVo	large_intestine	COSMIC	PRTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49841	Glycogen synthase kinase-3 beta	DEG_SPOP_SBC_1	5:9	PRTTS	SPOP	0.9966	More...
P50281	Matrix metalloproteinase-14	DEG_SPOP_SBC_1	297:301	PRTTS	SPOP	0.8919	More...
Q14678	KN motif and ankyrin repeat domain-containing protein 1	DEG_SPOP_SBC_1	76:80	PRTTS	SPOP	0.5682	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	4014:4018	PRTTS	SPOP	0.8354	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	618:622	PRTTS	SPOP	0.9725	More...
Q9ULD2	Microtubule-associated tumor suppressor 1	DEG_SPOP_SBC_1	602:606	PRTTS	SPOP	0.9839	More...
Q9Y2H0	Disks large-associated protein 4	DEG_SPOP_SBC_1	566:570	PRTTS	SPOP	0.9951	More...
Q9Y6T7	Diacylglycerol kinase beta	DEG_SPOP_SBC_1	119:123	PRTTS	SPOP	0.711	More...
Q504T8	Midnolin	DEG_SPOP_SBC_1	347:351	PRTTS	SPOP	0.9927	More...
Q15032	R3H domain-containing protein 1	DEG_SPOP_SBC_1	802:806	PRTTS	SPOP	0.9836	More...
Q96F83	Uncharacterized protein CLBA1	DEG_SPOP_SBC_1	110:114	PRTTS	SPOP	0.7739	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons