DegronMD - Q9P1A6(DLGAP2)

FUNCTION: May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane.

GO - Biological processes (BP): neuron-neuron synaptic transmission [GO:0007270]; regulation of postsynaptic neurotransmitter receptor activity [GO:0098962]

GO - Molecular function (MF): molecular adaptor activity [GO:0060090]

GO - Cellular component (CC): glutamatergic synapse [GO:0098978]; neurofilament [GO:0005883]; plasma membrane [GO:0005886]; postsynaptic density [GO:0014069]; postsynaptic specialization [GO:0099572]

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S75A	SIDM01263	T-Lymphoblastic Leukemia	GDSC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.87
p.R833W	WM35	skin	COSMIC	DYR	CBL_MET	831:833	Mutation altering degron motif	0.8634
p.S446R	ACH-000986	Colon/Colorectal Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.8538
p.S446R	HT-115	large intestine	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.8538
p.R58C	DO229160	NKTL	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.8301
p.R58H	DO44096	COAD	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.8244
p.S157P	SIDM02059	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7863
p.Q444L	ACH-000766	Lung Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7765
p.Q444L	NCI-H1648	lung	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7765
p.E445V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7693
p.E445V	HT	haematopoietic and lymphoid tissue	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7693
p.S60L	TCGA-CV-7568	HNSC	TCGA	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7667
p.S60L	DO14160	HNSC	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7667
p.G73C	ACH-000769	Lung Cancer	CCLE	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.76
p.G73C	LK-2	lung	COSMIC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.76
p.P57L	TCGA-32-2616	GBM	TCGA	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7582
p.P57L	DO13462	GBM	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7582
p.H75Q	TCGA-55-8302	LUAD	TCGA	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.7582
p.H75Q	DO45312	LUAD	ICGC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.7582
p.P395L	TCGA-BR-8361	STAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7582

Showing 1 to 20 of 213 entries

Previous1 2 3 4 5…11Next

No resistance data available for this Degron.

Kaplan plot for DLGAP2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLGAP2

UniProt ID: Q9P1A6

Entrez ID:

Protein name: Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

No resistance data available for this Degron.

Kaplan plot for DLGAP2 in