DegronMD - Q9P1A6(DLGAP2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E167K	TCGA-21-1079	LUSC	TCGA	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1111
p.E167K	DO26846	LUSC	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1111
p.G392R	TCGA-29-1762	OV	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7568
p.G392R	TCGA-BR-8078	STAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7568
p.G392R	DO29136	OV	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7568
p.G392R	DO38288	STAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7568
p.P57L	TCGA-32-2616	GBM	TCGA	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7582
p.P57L	DO13462	GBM	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7582
p.A381E	TCGA-33-4566	LUSC	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0556
p.A381E	DO26790	LUSC	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0556
p.Q640R	TCGA-3C-AALI	BRCA	TCGA	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1667
p.Q640R	DO219589	BRCA	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1667
p.S832I	TCGA-49-AAR2	LUAD	TCGA	DYR	CBL_MET	831:833	Mutation altering degron motif	0.7341
p.S832I	DO218918	LUAD	ICGC	DYR	CBL_MET	831:833	Mutation altering degron motif	0.7341
p.H75Q	TCGA-55-8302	LUAD	TCGA	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.7582
p.H75Q	DO45312	LUAD	ICGC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.7582
p.Q433H	TCGA-62-A46O	LUAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.0556
p.Q433H	DO26240	LUAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.0556
p.A381S	TCGA-64-1676	LUAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0556
p.A381S	DO23629	LUAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0556
p.L442M	TCGA-86-8674	LUAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.3056
p.L442M	DO25535	LUAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.3056
p.L823I	TCGA-A5-A2K5	UCEC	TCGA	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1111
p.L823I	TCGA-EO-A22U	UCEC	TCGA	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1111
p.L823I	DO43755	UCEC	ICGC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1111
p.L823I	DO41379	UCEC	ICGC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1111
p.V439I	TCGA-AA-A01X	COAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.3333
p.V439I	DO225059	BRCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.3333
p.V439I	DO8004	COAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.3333
p.V439I	DO233222	GACA	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.3333
p.V830I	TCGA-AB-2806	LAML	TCGA	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1667
p.V830I	TCGA-AB-2806	LAML	TCGA	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.3056
p.V830I	DO21283	LAML	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1667
p.V830I	DO21283	LAML	ICGC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.3056
p.R615Q	TCGA-AD-6888	COAD	TCGA	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.25
p.R615Q	DO10435	COAD	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.25
p.R150C	TCGA-AP-A0LM	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.R150C	DO43306	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.T616I	TCGA-B5-A3FC	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2778
p.T616I	DO41871	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2778
p.E453K	TCGA-BG-A221	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.1944
p.E453K	DO233135	GACA	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.1944
p.E453K	DO42384	UCEC	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.1944
p.P395L	TCGA-BR-8361	STAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7582
p.P395L	DO48032	STAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7582
p.S60L	TCGA-CV-7568	HNSC	TCGA	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7667
p.S60L	DO14160	HNSC	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.7667
p.V448M	TCGA-D1-A17C	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7208
p.V448M	DO222785	COCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7208
p.V448M	DO42841	UCEC	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7208
p.M837V	TCGA-D1-A17D	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7208
p.M837V	DO41746	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7208
p.F844L	TCGA-D1-A17Q	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2222
p.F844L	DO41903	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2222
p.A454V	TCGA-D5-5539	COAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.2778
p.A454V	TCGA-PZ-A5RE	PAAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.2778
p.A454V	DO9506	COAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.2778
p.A454V	DO49415	PAAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.2778
p.S635P	TCGA-DF-A2KU	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.S635P	DO223286	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.K158E	TCGA-DI-A1BU	UCEC	TCGA	VSSST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7022
p.K158E	DO42023	UCEC	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7022
p.W846C	TCGA-DX-AB2Q	SARC	TCGA	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1667
p.W846C	DO220087	SARC	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1667
p.G458E	TCGA-EB-A550	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.1667
p.G458E	DO47265	SKCM	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation substituting flanking lysine	0.1667
p.R615W	TCGA-EO-A22U	UCEC	TCGA	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.25
p.R615W	DO43755	UCEC	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.25
p.F644L	TCGA-EO-A22X	UCEC	TCGA	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0556
p.F644L	DO43907	UCEC	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.0556
p.Q834K	TCGA-ER-A19P	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2778
p.Q834K	TCGA-ER-A19P	SKCM	TCGA	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.3056
p.Q834K	DO47623	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2778
p.Q834K	DO47623	SKCM	ICGC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.3056
p.H399R	TCGA-FI-A2D0	UCEC	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.2778
p.H399R	DO43891	UCEC	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.2778
p.G824C	TCGA-FS-A1ZR	SKCM	TCGA	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1389
p.G824C	DO37651	SKCM	ICGC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1389
p.A438V	TCGA-FS-A1ZW	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.1944
p.A438V	DO227906	COCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.1944
p.A438V	DO37519	SKCM	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.1944
p.E385G	TCGA-G4-6302	COAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1667
p.E385G	DO8778	COAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1667
p.P82Q	TCGA-GF-A2C7	SKCM	TCGA	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.1944
p.P82Q	DO37407	SKCM	ICGC	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.1944
p.D74N	TCGA-HF-7132	STAD	TCGA	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.6932
p.D74N	DO38214	STAD	ICGC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.6932
p.R83W	TCGA-HU-A4G8	STAD	TCGA	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.1667
p.R83W	DO47819	STAD	ICGC	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.1667
p.Q406R	TCGA-MX-A5UJ	STAD	TCGA	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0833
p.Q406R	DO233871	GACA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0833
p.Q406R	DO48547	STAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.0833
p.R148Q	TCGA-QC-A7B5	SARC	TCGA	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.R148Q	DO233693	GACA	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.R148Q	DO220239	SARC	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1389
p.H85Q	TCGA-RQ-AAAT	DLBC	TCGA	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.1111
p.H85Q	DO219924	DLBC	ICGC	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.1111
p.A626V	TCGA-VQ-A8P2	STAD	TCGA	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.A626V	TCGA-VQ-A8P2	STAD	TCGA	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.A626V	DO234446	ESAD	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.A626V	DO234446	ESAD	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.A626V	DO233106	GACA	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.A626V	DO233106	GACA	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.A626V	DO51761	STAD	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.A626V	DO51761	STAD	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.A45T	TCGA-VQ-AA6D	STAD	TCGA	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.0556
p.A45T	DO233885	GACA	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.0556
p.A45T	DO222392	STAD	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.0556
p.G50R	TCGA-WE-A8ZQ	SKCM	TCGA	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.1944
p.G50R	DO51288	SKCM	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.1944
p.G50R	ACH-001624	Brain Cancer	CCLE	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.1944
p.R58H	DO44096	COAD	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.8244
p.V156M	DO222765	COCA	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7208
p.P384Q	DO229010	COCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation substituting flanking lysine	0.25
p.P384Q	DO229013	COCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation substituting flanking lysine	0.25
p.P384Q	DO229003	COCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation substituting flanking lysine	0.25
p.P384Q	DO229489	LAML	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation substituting flanking lysine	0.25
p.R150H	DO50451	ESAD	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1944
p.Q610H	DO50438	ESAD	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation substituting flanking lysine	0.2222
p.Q402E	DO234334	ESAD	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1944
p.D641N	DO222701	ESCA	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1389
p.R54H	DO233193	GACA	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.3056
p.R54H	ACH-000979	Prostate Cancer	CCLE	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.3056
p.S434N	DO233634	GACA	ICGC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.0833
p.Y845H	DO233621	GACA	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1944
p.A626T	DO27813	MALY	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.2222
p.A626T	DO27813	MALY	ICGC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2222
p.A620T	DO220879	MELA	ICGC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.7139
p.G51E	DO220895	MELA	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.2222
p.P69L	DO220913	MELA	ICGC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.7582
p.R58C	DO229160	NKTL	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.8301
p.S163L	DO50729	ORCA	ICGC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2222
p.Q839H	DO221540	PACA	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7582
p.F844C	DO36556	READ	ICGC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2222
p.R52C	DO38404	STAD	ICGC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.25
p.R52C	ACH-000963	Colon/Colorectal Cancer	CCLE	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.25
p.L388P	DO229213	THCA	ICGC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.25
p.K392T	SIDM02050	Colorectal Carcinoma	GDSC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation altering degron motif	0.7306
p.S157P	SIDM02059	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation altering degron motif	0.7863
p.E445V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7693
p.E445V	HT	haematopoietic and lymphoid tissue	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7693
p.T66M	SIDM00933	Breast Carcinoma	GDSC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.2778
p.T66M	SIDM00933	Breast Carcinoma	GDSC	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.25
p.T66M	CAL-51	breast	COSMIC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.2778
p.T66M	CAL-51	breast	COSMIC	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.25
p.V629M	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.V629M	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.V629M	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1389
p.V629M	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.T613K	SIDM00120	Prostate Carcinoma	GDSC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1944
p.T613K	DU-145	prostate	COSMIC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1944
p.G153C	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2778
p.G153C	LK-2	lung	COSMIC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.2778
p.H169Y	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.H169Y	REH	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0556
p.R834W	SIDM00974	Melanoma	GDSC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2778
p.R834W	SIDM00974	Melanoma	GDSC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.3056
p.R834W	WM35	skin	COSMIC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2778
p.R834W	WM35	skin	COSMIC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.3056
p.S75A	SIDM01263	T-Lymphoblastic Leukemia	GDSC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.87
p.P401A	SIDM00512	Non-Small Cell Lung Carcinoma	GDSC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.2222
p.D56N	SIDM00853	Other Sarcomas	GDSC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.6932
p.D56N	GCT	soft tissue	COSMIC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.6932
p.F827L	SIDM01187	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation blocking phosphorylation signal	0.5278
p.F827L	SIDM01187	Breast Carcinoma	GDSC	DYR	CBL_MET	831:833	Mutation blocking phosphorylation signal	0.6667
p.F827L	UACC-812	breast	COSMIC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation blocking phosphorylation signal	0.5278
p.F827L	UACC-812	breast	COSMIC	DYR	CBL_MET	831:833	Mutation blocking phosphorylation signal	0.6667
p.S168L	SIDM00534	Colorectal Carcinoma	GDSC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.S168L	HT-115	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.A641T	SIDM00220	Ovarian Carcinoma	GDSC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1389
p.A641T	OC-314	ovary	COSMIC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1389
p.R434K	SIDM01611	Endometrial Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation rewiring degron network	0.0833
p.H154Y	ACH-000024	Myeloma	CCLE	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.H154Y	OPM-2	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.3056
p.Y404C	ACH-000156	Leukemia	CCLE	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1389
p.Y404C	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1389
p.Q444L	ACH-000766	Lung Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7765
p.Q444L	NCI-H1648	lung	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7765
p.G73C	ACH-000769	Lung Cancer	CCLE	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.76
p.G73C	LK-2	lung	COSMIC	NEERYSPAP	CBL_PTK	69:77	Mutation altering degron motif	0.76
p.R54S	ACH-000871	Lung Cancer	CCLE	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.3056
p.S443R	ACH-000900	Lung Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7427
p.S443R	NCI-H23	lung	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.7427
p.S446R	ACH-000986	Colon/Colorectal Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.8538
p.S446R	HT-115	large intestine	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.8538
p.P386L	ACH-000999	Colon/Colorectal Cancer	CCLE	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1944
p.P386L	SNU-1040	large intestine	COSMIC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.1944
p.S635F	ACH-001002	Skin Cancer	CCLE	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.S635F	451Lu	skin	COSMIC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.3056
p.C48F	ACH-001028	Rhabdoid	CCLE	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.1389
p.C848S	ACH-001991	Primary	CCLE	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1111
p.T841A	NCI-H630	large intestine	COSMIC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.3056
p.T841A	NCI-H630	large intestine	COSMIC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1111
p.P618S	NCI-H1417	lung	COSMIC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.6752
p.G152C	LK-2	lung	COSMIC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.25
p.E444V	HT	haematopoietic and lymphoid tissue	COSMIC	DEESGE	DEG_Kelch_Keap1_1	443:448	Mutation altering degron motif	0.6582
p.Q400L	EMC-BAC-2	lung	COSMIC	KPLLHQD	LIG_APCC_ABBAyCdc20_2	391:397	Mutation rewiring degron network	0.25
p.A640T	OC-314	ovary	COSMIC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.1667
p.R833W	WM35	skin	COSMIC	DYR	CBL_MET	831:833	Mutation altering degron motif	0.8634
p.T612K	DU-145	prostate	COSMIC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation blocking phosphorylation signal	0.6111
p.V628M	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.1667
p.V628M	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	AQSST	DEG_SPOP_SBC_1	630:634	Mutation rewiring degron network	0.2778
p.R87W	DND-41	haematopoietic and lymphoid tissue	COSMIC	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.0556
p.H168Y	REH	haematopoietic and lymphoid tissue	COSMIC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.0833
p.F826L	UACC-812	breast	COSMIC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.0556
p.F826L	UACC-812	breast	COSMIC	DYR	CBL_MET	831:833	Mutation rewiring degron network	0.1944
p.P617S	NCI-H1417	lung	COSMIC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation rewiring degron network	0.3056
p.S167L	HT-115	large intestine	COSMIC	VSSST	DEG_SPOP_SBC_1	155:159	Mutation rewiring degron network	0.1111
p.T65M	CAL-51	breast	COSMIC	DLDPQYSWSP	CBL_PTK	55:64	Mutation rewiring degron network	0.3056
p.T65M	CAL-51	breast	COSMIC	NEERYSPAP	CBL_PTK	69:77	Mutation rewiring degron network	0.2222
p.D618N	639-V	urinary tract	COSMIC	PRTTS	DEG_SPOP_SBC_1	618:622	Mutation altering degron motif	0.6932
p.T840A	NCI-H630	large intestine	COSMIC	VDTST	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7139
p.D55N	GCT	soft tissue	COSMIC	DLDPQYSWSP	CBL_PTK	55:64	Mutation altering degron motif	0.5821

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DLGAP2

UniProt ID: Q9P1A6

Entrez ID:

Protein name: Disks large-associated protein 2 (DAP-2) (PSD-95/SAP90-binding protein 2) (SAP90/PSD-95-associated protein 2) (SAPAP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DLGAP2 in