DegronMD

Uniprot ID: Q9P1A6

Source protein: Disks large-associated protein 2

Source gene: DLGAP2

Class: DEG_Kelch_Keap1_1

Location: 443:448

E3 ligase: KEAP1

DEGRON score: 0.6369

ASA_SCORE: 99.0333

COIL: 0.8557

CONS_SCORE: 0.4331

DSS_SCORE: 0.6994

HELIX: 0.0987

FCONS_SCORE: 0.8528

RIG_SCORE: 0.5577

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q433H	TCGA-62-A46O	LUAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.0556
p.Q433H	DO26240	LUAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.0556
p.L442M	TCGA-86-8674	LUAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.3056
p.L442M	DO25535	LUAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.3056
p.V439I	TCGA-AA-A01X	COAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.3333
p.V439I	DO225059	BRCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.3333
p.V439I	DO8004	COAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.3333
p.V439I	DO233222	GACA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.3333
p.E453K	TCGA-BG-A221	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.1944
p.E453K	DO233135	GACA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.1944
p.E453K	DO42384	UCEC	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.1944
p.V448M	TCGA-D1-A17C	UCEC	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.7208
p.V448M	DO222785	COCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.7208
p.V448M	DO42841	UCEC	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.7208
p.A454V	TCGA-D5-5539	COAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.2778
p.A454V	TCGA-PZ-A5RE	PAAD	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.2778
p.A454V	DO9506	COAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.2778
p.A454V	DO49415	PAAD	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.2778
p.G458E	TCGA-EB-A550	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.1667
p.G458E	DO47265	SKCM	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.1667
p.A438V	TCGA-FS-A1ZW	SKCM	TCGA	DEESGE	DEG_Kelch_Keap1_1	0.1944
p.A438V	DO227906	COCA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.1944
p.A438V	DO37519	SKCM	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.1944
p.S434N	DO233634	GACA	ICGC	DEESGE	DEG_Kelch_Keap1_1	0.0833
p.E445V	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	0.7693
p.E445V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.7693
p.R434K	SIDM01611	Endometrial Carcinoma	GDSC	DEESGE	DEG_Kelch_Keap1_1	0.0833
p.Q444L	ACH-000766	Lung Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	0.7765
p.Q444L	NCI-H1648	lung	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.7765
p.S443R	ACH-000900	Lung Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	0.7427
p.S443R	NCI-H23	lung	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.7427
p.S446R	ACH-000986	Colon/Colorectal Cancer	CCLE	DEESGE	DEG_Kelch_Keap1_1	0.8538
p.S446R	HT-115	large_intestine	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.8538
p.E444V	HT	haematopoietic_and_lymphoid_tissue	COSMIC	DEESGE	DEG_Kelch_Keap1_1	0.6582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q02952	A-kinase anchor protein 12	DEG_Kelch_Keap1_1	541:546	DEESGE	KEAP1	0.9956	More...
Q9P1A6	Disks large-associated protein 2	DEG_Kelch_Keap1_1	443:448	DEESGE	KEAP1	0.6369	More...
Q96M83	Coiled-coil domain-containing protein 7	DEG_Kelch_Keap1_1	822:827	DEESGE	KEAP1	0.804	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DEESGE

Degron related mutations and impact score

Drug responses associated with DLGAP2 mutations

All proteins holding degron of DEESGE